E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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Editor-in-Chief:
William A. Banks
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Articles Ahead of Print

Nanovesicular Formulations for Cancer Gene Therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo


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Long-lasting Insulin Treatment Via a Single Subcutaneous Administration of Liposomes in Thermoreversible Pluronic® F127 Based Hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu and Zhijun Yang


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Anti-Cancer Drug Delivery Using Carbohydrate-Based Polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani


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Approaches of the Transcriptomic Analysis in Astrocytes: Potential Pharmacological Targets


George E. Barreto , Rosa M. Gómez, Rosa Helena Bustos, Diego A. Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria and Janneth Gonzalez


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Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells


Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla


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Statins and Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis


Alexandros Briasoulis, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis


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Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells


Byeong Mo Kim, Wonsuck Yoon, Jung-Hyun Shim, Haiyoung Jung, Ji Hong Lim, Hyun-Jung Choi, MiRan Seo, Tae Ho Lee and Sang-Hyun Min


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Beneficial Effects of Corn Silk on Metabolic Syndrome


Bing Wang, Tiegang Xiao, Jun Ruan and Wensheng Liu


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A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure


Yong Wang, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu and Wei Wang


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Natural Active Compounds from Plant Food and Chinese Herbal Medicine for Nonalcoholic Fatty Liver Disease


Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu and Qin Feng


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Chinese Herbal Medicine for the Treatment of Depression: Applications, Efficacies and Mechanisms


Yuanyuan Wang, Menglin Li, Yan Liang, Yiting Yang, Zhe Liu, Keyu Yao, Zijie Chen and Shuangqing Zhai


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An Overview of Cardenolides in Digitalis - More Than a Cardiotonic Compound


Ekrem Gurel, Serhan Karvar, Buhara Yucesan, Ismail Eker and Muhammad Sameeullah


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The Therapeutical Effect of Chinese Medicine for the Treatment of Atherosclerotic Coronary Heart Disease


Jian Zhang , Hui Meng, Yi Zhang , Xuefeng Zhang , MingYan Shao, Chun Li and Pengfei Tu


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Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants


Robert B. Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit CP Koch, Ronald de Groot, Dick Tibboel, Catherijne AJ Knibbe, Irwin KM Reiss, Sinno HP Simons and DINO Research group


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A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension


Louise Marqvard Sørensen, Markus Wehland, Marcus Krüger, Ulf Simonsen, Mohamed Zakaria Nassef, Manfred Infanger and Daniela Grimm


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Why Not All Hypertensive Patients Are Tachycardic at Rest?


Maciej Siński, Piotr Jędrusik and Jacek Lewandowski


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PD-1/PD-L1 Inhibitors for Immuno-oncology: From Antibodies to Small Molecules


Qiaohong Geng, Peifu Jiao, Peng Jin, Gaoxing Su, Jinlong Dong and Bing Yan


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Statins in Diabetes Mellitus


Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, George Lazaros and Dimtris Tousoulis


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Editorial: Astrocyte-Targeted Therapeutic Strategies for Neurological Disorders


Ikuko Miyazaki





IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development


Ann Hellstrom, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard


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Astroglial Connexins as a Therapeutic Target for Alzheimer's Disease


Chenju Yi, Annette Koulakoff and Christian Giaume


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Sexual Dysfunction in Epilepsy and the Role of Anti-Epileptic Drugs


Mahinda Yogarajah and Marco Mula


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Hair Analysis in Forensic Toxicology: An Updated Review with a Special Focus on Pitfalls


Pascal Kintz


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Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review


JC. Alvarez, N. Fabresse and IA. Larabi


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Nails in Forensic Toxicology: An Update


Renata Solimini, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò


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Medicinal Plants as Protective Strategies Against Parkinson’s Disease


Natalia Areiza Mazo, Valentina Echeverria, Ricardo Cabezas, Marco Ávila-Rodriguez, Gjumrakch Aliev, Jerzy Leszek and George E. Barreto


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Therapeutic Drug Monitoring in Neonates: What Makes them Unique?


P. Mian, R. B. Flint, D. Tibboel, J. N. van den Anker, K. Allegaert and B. C.P. Koch


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Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines


Karin Kogermann, Jana Lass, Georgi Nellisd, Tuuli Metsvaht and Irja Lutsar


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Analgesics in Pregnancy: An Update on Use, Safety and Pharmacokinetic Changes in Drug Disposition


Hayley R Price and Abby C Collier


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Modelling Bronchopulmonary Dysplasia in Animals: Arguments for the Preterm Rabbit Model


Thomas Salaets, Andre Gie, Bieke Tack, Jan Deprest and Jaan Toelen


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Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation


Gaetano Terrone, Alessia Salamone and Annamaria Vezzani


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The Use of Hemodynamic and Cerebral Monitoring to Study Pharmacodynamics in Neonates


A. Smits, L. Thewissen, A. Dereymaeker, E. Dempsey, A. Caicedo and Gunnar Naulaers


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Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities


Pisani Laura Rosa, Nikanorova Marina, Johannessen Landmark Cecilie, Johannessen Svein Ivor and Pisani Francesco


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Long-term Effects of Early Exposure to Stress, Pain, Opioids and Anaesthetics on Pain Sensitivity and Neurocognition


Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel and Jurgen C. de Graaff


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Diabetes-Related Neurological Implications and Pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa


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Modulation of both Insulin Resistance and Cancer Growth by Inositol


Mariano Bizzarri, Simona Dinicola and Alessandra Cucina


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Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee


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Role of Bradykinin in the Regulation of Endothelial Nitric Oxide Synthase Expression by Cardiovascular Drugs


Jin Bo Su


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Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives


Antonio Gambardella, Angelo Labate, Laura Mumoli, Iscia Lopes-Cendes and Fernando Cendes


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Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases


Wei Chen and Guoxun Chen


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The Efficacy and Potential Mechanisms of Chinese Herbal Medicine on Irritable Bowel Syndrome


Zijuan Bi, Yu Zheng, Jianye Yuan and Zhaoxiang Bian


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Imaging Biomarkers of Anti-Epileptic Drug Action: Insights from Magnetic Resonance Imaging


Lorenzo Caciagli, Fenglai Xiao, Britta Wandschneider and Matthias J. Koepp


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MiRNA-based Therapeutic Strategy in Lung Cancer


Guang Li, Jing Fang, Ying Wang, Hu Wang and Cheng-Cao Sun


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Role of miRNA in Lung Cancer-Potential Biomarkers and Therapies


Xiaohong Du, Jitai Zhang, Juping Wang, Xiaoming Lin and Feng Ding


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MiRNA-based Therapeutics for Lung Cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng and Yibing Xu


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Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu


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Good Practices in Forensic Toxicology


Olaf H. Drummer


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LSD Detection and Interpretation in Hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier


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Overview of Forensic Toxicology, Yesterday, Today and in the Future


Heesun Chung and Sanggil Choe


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Method Development in Forensic Toxicology


Frank T. Peters, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini


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The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier


Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang


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Allopurinol: Old Drug, New Indication in Neonates?


Kim V Annink, Axel R Franz, Jan B Derks, Mario Rüdiger, Frank van Bel and Manon J.N.L. Benders


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Sialidases: Therapeutic and Antiatherogenic Potential


Vasily Nikolaevich Sukhorukov , Vasily Petrovich Karagodin , Emile Rustemovich Zakiev , Andrey Vyacheslavovich Grechko and Alexandr Nikolaevich Orekhov


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Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data


Ebru Ergenekon, Héctor Rojas-Anaya, María Carmen Bravo, Charalampos Kotidis, Liam Mahoney and Heike Rabe


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Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach


Adriana Trompetero, Aldemar Gordillo, Carolina del Pilar Mora, María Cristina Velasquillo and Rosa Helena Bustos


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Synthesis and Biological Evaluation of New Tyrosol-Salicylate Derivatives as Potential Anti-Inflammatory Agents


Rafael P. Aguiar, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K. N. Cuman


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Percutaneous Treatment of Aortic Valve Disease: Contemporary Overview and Future Trends


Marko Banovic, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric and Bernard Iung


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Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


Luis E. Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Graciela Zambrano-Galván and Fernando Guerrero-Romero


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Formulation, Quality Control and Safety Issues of Nanocarriers Used for Cancer Treatment


Ismael D. Bianco, Marcelo R. Ceballos, Cristian Casado, Viviana G. Dabbene, Carolina Rizzi and R. Kiyomi Mizutamari


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Management of Blood Pressure and Heart Rate in Patients with Diabetes Mellitus


Ioanna Gouni-Berthold, Ruth Hanssen, Lisa Ravarani and Heiner K. Berthold


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What is the Real Efficacy of Beta-Blockers for the Treatment of Essential Hypertension?


Christian Höcht, Facundo M Bertera, Julieta S Del Mauro, Yanina Santander Plantamura, Carlos A Taira and Ariel H Polizio


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The “Neurocentric” Approach to Essential Hypertension: How Reliable is the Paradigm of Hyperkinetic Hypertension? A Focus on the Sympathetic Nervous System Dysregulation in Essential Hypertensive Patients with Elevated Resting Heart Rate


Domenico Di Raimondo, Gaia Musiari, Mauro Grova, Giuseppe Miceli, Antonino Tuttolomondo and Antonio Pinto


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Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer


Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Prashant Kesharwani and Umesh Gupta


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Management of Blood Pressure and Heart Rate in Chronic Kidney Disease


Antonia Kaltsatou


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Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments


Alexandra Muñoz Bonilla and Pilar Herrasti González


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Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery


Jaleh Varshosaz, Somayeh Taymouri and Erfaneh Ghassami


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Modulation of Heart Rate by Acute or Chronic Aerobic Exercise. Potential Effects on Blood Pressure Control


Carme Perez-Quilis, J. Derek Kingsley, Kabir Malkani, Gianfranco Cervellin, Giuseppe Lippi and Fabian Sanchis-Gomar


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Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy


Ahmed Elzoghby, May Freag, Hadeer Mamdouh and Kadria Elkhodairy


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Albumin Nanocarriers, γ - Irradiated Crosslinked, Combined with Therapeutic Drugs for Cancer Therapy


Macarena Siri, Estefanía Achilli, Mariano Grasselli and Silvia del V. Alonso


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Using Properties of Tumor Microenvironments for Controlling Local, On-Demand Delivery from Biopolymer-Based Nanocarriers


Abdullah K. Alshememry, Suleiman S. El-Tokhy and Larry D. Unsworth


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Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications


Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev and Mohammad Amjad Kamal


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Editorial: Recent Advances in the Field of Kinases and Kinase Inhibitors


Zunnan Huang and Mee-Hyun Lee





Ketogenic Diets in the Treatment of Epilepsy


Maurizio Elia, Joerg Klepper, Baerbel Leiendecker and Hans Hartmann


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Management of Antiepileptic Treatment After Epilepsy Surgery - Practices and Problems


Guido Rubboli, Anne Sabers, Peter Uldall and Kristina Malmgren


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Antiepileptic Treatments in Developing Countries


Jeremy Jost, Athanase Millogo and Pierre-Marie Preux


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Treatment of Epileptic Encephalopathies


Simona Balestrini and Sanjay M Sisodiya


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Protein Kinases as Tumor Biomarkers and Therapeutic Targets


Chuntao Quan, Juanjuan Xiao, Lin Liu, Qiuhong Duan, Ping Yuan and Feng Zhu


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Application of Kinase Inhibitors for Anti-Aging Intervention


Mercedes Cano, Antonio Ayala, Francesco Marotta and Sandro Argüelles


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GSK3 Inhibitors in the Therapeutic Development of Diabetes, Cancer and Neurodegeneration: Past, Present and Future


Mudasir Maqbool and Nasimul Hoda


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Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme: Linking Basic Studies to Clinical Applications


Aidong Zhou


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Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV


Yong Cheng, Jeffrey S. Schorey, Cheng-Cai Zhang and Xuejuan Tan


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The Role of Exosomes and Exosome-derived microRNAs in Atherosclerosis


Xinjie Lu


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Implications of Photophysical and Physicochemical Factors on Successful Application of Photodynamic Therapy


Shubhajit Paul, Paul Wan Sia Heng and Lai Wah Chan


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Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases


Chongshan Liao, Chengfei Zhang and Yanqi Yang


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Nanotechnology in Neurosciences: An Approach


Rosa Helena Bustos, M. Magdy Sanchez, Maria Andrea Dominguez-Sanchez, George E. Barreto, Daniel Lancheros and Jorge Reynolds


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Biotin and Glutathione Targeting of Solid Nanoparticles to Cross Human Brain Endothelial Cells


Szilvia Veszelka, Mária Mészáros, Lóránd Kiss, Zoltán Kóta, Tibor Páli, Zsófia Hoyk, Zsolt Bozsó, Lívia Fülöp, András Tóth, Gábor Rákhely and Mária A. Deli


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Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting


Svetlana Vinokurova


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Neuroglial Cell Cryopreservation in Appropriate Inductive Conditions


Rosa M. Gomez, Maria Andrea Dominguez-Sanchez, Magdy M. Sanchez and George E. Barreto


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Role of the Immune Component of Tumor Microenvironment in the Efficiency of Cancer Treatment: Perspectives for the Personalized Therapy


Marina Stakheyeva, Vladimir Riabov, Irina Mitrofanova, Nikolai Litviakov, Evgeny Choynzonov, Nadezhda Cherdyntseva and Julia Kzhyshkowska


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DNA Base Excision Repair: The Achilles’ Heel of Tumour Cells and their Microenvironment


M Poletto , A J Legrand and G L Dianov


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Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study


Nivedita Singh, Sherry Freiesleben, Shailendra K. Gupta, Yogeshwer Shukla and Olaf Wolkenhauer


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Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils


Sandra Völs, Ronit Vogt Sionov and Zvi Granot


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Membrane-bound ATP-dependent Energy Systems, as Extra- and Intracellular Key Signals for Gastrointestinal Functions and their Regulations in the Gastrointestinal Mucosa


Gyula Mózsik, Imre László Szabó and József Czimmer


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Modulation of GABAA Receptors in the Treatment of Epilepsy


Eleonora Palma, Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Erwin A. van Vliet and Eleonora Aronica


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Update on Pharmacological Treatment of Progressive Myoclonus Epilepsies.


Edoardo Ferlazzo, Dorothee Kasteleijn-Nolst Trenite, Gerrit-Jan de Haan, Felix Felix Nitschke, Saija Ahonen, Sara Gasparini and Berge A. Minassian


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Antiepileptic Drugs in Clinical Development: Differentiate or Die?


Gaetano Zaccara and D. Schmidt


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Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review


Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri and Giovambattista De Sarro


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Protein Kinases as Targets for Opisthorchis viverrini- Associated Cholangiocarcinoma Therapy


Watcharin Loilome and Hasaya Dokduang


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Discovery and Development of ATP-Competitive mTOR Inhibitors Using Computational Approaches


Yao Luo and Ling Wang


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Induction of Synthetic Lethality by Natural Compounds Targeting Cancer Signaling


Lee Farrand and Sanguine Byun


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Protein Tyrosine Signaling and its Potential Therapeutic Implications in Carcinogenesis


Mihwa Kim, Minwoo Baek and Dae Joon Kim


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Nano-sized Ultrasound Contrast Agents for Cancer Therapy and Theranostics


Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng and Zi-Ping Li


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Potentially Clinically Relevant Pharmacodynamic Interactions Between Antiepileptic Drugs and Psychotropic Drugs: An Update


Edoardo Spina and Jose de Leon


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The Relevance of Post-Transcriptional Mechanisms in HIV Latency Reversal


Ambra Sarracino and Alessandro Marcello


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Targeting CD147 is a Novel Strategy for Antitumor Therapy


ChengXiang Lian, Yeye Guo, Jianglin Zhang, Xiang Chen and Cong Peng


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The HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies


Andrew P. Rice


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Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals


Xionghao Lin, Tatyana Ammosova, Namita Kumari and Sergei Nekhai


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Dual Roles of Pin1 in Cancer Development and Progression


Hyeong-jun Han, Bu Young Choi and Young-Joon Surh


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Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription


Guillaume Mousseau and Susana T. Valente


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HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency


Yao A. Akpamagbo, Catherine DeMarino, Michelle L. Pleet, Angela Schwab, Myosotys Rodriguez, Robert A. Barclay, Gavin Sampey, Sergey Iordanskiy, Nazira El-Hage and Fatah Kashanchi


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Management of Blood Pressure and Heart Rate in Patients with Acute Stroke


Carlo Maida, Antonino Tuttolomondo, Domenico Di Raimondo and Antonio Pinto


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Molecular Targeting of ERKs/RSK2 Signaling in Cancers


Yong-Yeon Cho


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The Lipid-Lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation


Jerad H Dumolt and Todd C Rideout


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Current and Emerging Strategies in Osteoporosis Management


Stefka Ivanova and Liliya Vasileva


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The Role of Stress in Inflammatory Bowel Diseases


Dolores Sgambato, Agnese Miranda, Rocco Ranaldo, Alessandro Federico and Marco Romano


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Molecular Tests for the Choice of Cancer Therapy


Anna P. Sokolenko and Evgeny N. Imyanitov


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Recent Advances in the Function of the 67 kDa Laminin Receptor and its Targeting for Personalized Therapy in Cancer


Ada Pesapane, Pia Ragno, Carmine Selleri and Nunzia Montuori


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Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery


Trevor Clancy, Ruth Dannenfelser, Olga Troyanskaya, Karl Johan Malmberg, Eivind Hovig and Vessela Kristensen


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Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease


Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao and Shao Li


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New Strategies for the Prevention and Treatment of Systemic and Local Bone Loss; from Pathophysiology to Clinical Application


A. Fassio, Maurizio Rossini , Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato and Davide Gatti


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Altered Homeostatic Functions in Reactive Astrocytes and Their Potential as a Therapeutic Target After Brain Ischemic Injury


Helena Pivonkova and Miroslava Anderova


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Targeting Human Astrocytes’ Calcium-sensing Receptors for Treatment of Alzheimer’s Disease


Anna Chiarini, Ubaldo Armato, James F. Whitfield and Ilaria Dal Pra


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Astrocyte: An Innovative Approach for Alzheimer's Disease Therapy


Maria Rosanna Bronzuoli, Roberta Facchinetti, Luca Steardo and Caterina Scuderi


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Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease


Ikuko Miyazaki and Masato Asanuma


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Emerging Targets to Relieve Fat Stress-Induced Liver Diseases: UDCA, Tocotrienol, ω-3 PUFAs, and IgY Targeted NPC1L1 Cholesterol Transporter


Ji-Young Cha, Jong-Min Park, Ho-Jae Lee, Jin-Sik Bae, Young-Min Han, Byung-Chul Oh, Kwang Hyun Ko and Ki-Baik Hahm


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Class A GPCRs: Structure, Function, Modeling and Structure-based Ligand Design


Xiaojing Cong, Jérémie Topin and Jérôme Golebiowski


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The Tat/P-TEFb Protein-Protein Interaction Determining Transcriptional Activation of HIV


Kaori Asamitsu and Takashi Okamoto


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Plasmodial Hsp40s: New Avenues for Antimalarial Drug Discovery


Michael O Daniyan and Gregory L Blatch


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Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis


Yi-Ping Chou, Yin-Ku Lin, Chun-Han Chen and Jia-You Fang


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Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges


Yuan Ling, Zikang Zhang, Hua Zhang and Zunnan Huang


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Potential Application of 5-Aryl-Substituted 2-Amino-benzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals


Shinichi Uesato, Yoshiyuki Hirata and Tsutomu Sasaki


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Antidiabetic Drugs and the Kidney


Moses Elisaf, Eleftheria Tzavela, Nikolaos Karanatsis and Vasilis Tsimihodimos


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Targeting Astrocytes for Treating Neurological Disorders: Carbon Monoxide and Noradrenaline-Induced Increase in Lactate


Anemari Horvat, Nina Vardjan and Robert Zorec


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Post Mortem Redistribution of Drugs: Current State of Knowledge


Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti and Anne-Laure Pelissier-Alicot


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Metallothionein is a Potential Therapeutic Strategy for Amyotrophic Lateral Sclerosis


Shin-ichi Ono


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GLT-1 Upregulation as a Potential Therapeutic Target for Ischemic Brain Injury


Yu-Yan Hu, Li Li, Xiao-Hui Xian, Min Zhang, Xiao-Cai Sun, Shu-Qin Li, Xin Cui, Jie Qi and Wen-Bin Li


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Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis


Mariana Pehar, Benjamin A. Harlan, Kelby M. Killoy and Marcelo R. Vargas


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Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy


Anna Zajakina, Karina Spunde and Kenneth Lundstrom


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Astrocytes Pathology in ALS: A Potential Therapeutic Target?


Sonja Johann


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Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis


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Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer


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Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases


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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications


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May S Freag


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Micelles As Delivery System for Cancer Treatment


Dilek Keskin and Ayşen Tezcaner


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Management of Blood Pressure and Heart Rate in Acute Decompensated Heart Failure with Volume Overload


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Ligand-modified Biopolymeric Nanoparticles as Efficient Tools for Targeted Cancer Therapy


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Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds


Maria Yanez, James Blanchette and Ehsan Jabbarzadeh


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Pharmacological Treatment of Bone Loss


Rui Pang and Weibo Xia


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‘Osteoimmunology’ Offers New Perspectives for the Treatment of Pathological Bone Loss


Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li and Jie Guo


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Prospect of Combination and Sequential Therapies for Postmenopausal Osteoporosis


Hao Liu and Binbin Li


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Stress, Neuropeptides and Gastric Mucosa


Klara Gyires and Ágnes Fehér


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Low Testosterone Levels and Metabolic Syndrome in Aging Male


Rodrigo Blaya, Patrícia Blaya, Luiza Rhoden and Ernani Luis Rhoden


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Fertility and Sperm Quality in the Aging Male


Susana Almeida, Luís Rato, Mário Sousa, Marco G. Alves and Pedro F. Oliveira


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Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor


Kristian Leisegang, Ralf Henkel and Ashok Agarwal


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Unravelling the Power of Omics for the Infertile Ageing Male


Paulo Bastos, Maria João Freitas, André Gomes, Rui Vitorino and Margarida Fardilha


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Global Effects Of Early Life Stress On Neurons And Glial Cells


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Editorial: Pharmaceutical Applications of Dendrimers


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Angiogenesis and Oxidative Stress in Metastatic Tumor Progression: Pathogenesis and Novel Therapeutic Approach of Colon Cancer


Kathy K. Auyeung and Joshua K. Ko


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Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function


József Czimmer and Yvette Taché


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A Rat Model of Ischemic Enteritis: Pathogenic Importance of Enterobacteria, iNOS/NO, and COX-2/PGE2


Koji Takeuchi, Yoshino Komatsu, Yuka Nakamori and Tohru Kotani


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Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution?


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Recent Advances in the Gastric Mucosal Protection Against Stress-induced Gastric Lesions. Importance of Renin-angiotensin Vasoactive Metabolites, Gaseous Mediators and Appetite Peptides


Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki and Ryszard Korbut


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Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids


Ludmila Filaretova


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Stress and Salivary Glands


Beáta Kerémi, Anita Beck, Tibor Károly Fábián, Gábor Fábián, Géza Szabó, Ákos Nagy and Gábor Varga


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GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders


Maja Jazvinšćak Jembrek, Michelangelo Auteri, Rosa Serio and Josipa Vlainić


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Significance of Cholinergic and Peptidergic Nerves in Stress-Induced Ulcer and MALT Lymphoma Formation


Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y. Murayama and Hidenori Matsui


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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress


Akinori Yanaka


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Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products


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