Open Access Articles ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 24, 42 Issues, 2017


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Current Medicinal Chemistry

This journal supports open access

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  • 16th of 60 in Chemistry & Medicinal

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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5 - Year: 3.508

Open Access Articles

Therapeutic Strategies of Plant-derived Compounds for Diabetes Via Regulation of Monocyte Chemoattractant Protein-1

, 2017; 24(14): 1453 - 1468

Magdalena Czemplik, Anna Kulma, Yu Fu Wang and Jan Szopa


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Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

, 2017; 24(5): 529 - 536

Nuria Alegret, Alejandro Criado and Maurizio Prato


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Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

, 2017; 24: 1 - 10 (E-Pub Ahead of Print)

Yasushi Ikarashi, Kyoji Sekiguchi and Kazushige Mizoguchi


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Mycosporine-Like Amino Acids for Skin Photoprotection

, 2017; 24: 1 - 16 (E-Pub Ahead of Print)

Karl P Lawrence, Paul F Long and Antony R Young


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NGS Technologies as a Turning Point in Rare Disease Research, Diagnosis, and Treatment

, 2017; 24: 1 - 29 (E-Pub Ahead of Print)

Ana Fernández-Marmiesse, Sofía Gouveia and María L. Couce


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A Therapeutic Connection Between Dietary Phytochemicals and ATP Synthase

, 2017; 24: 1 - 13 (E-Pub Ahead of Print)

Zulfiqar Ahmad, Sherif S Hassan and Sofiya Azim


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Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development

, 2017; 24: 1 - 14 (E-Pub Ahead of Print)

Tatiana I. Samoylova, Timothy D. Braden, Jennifer A. Spencer and Frank F. Bartol


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Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme

, 2016; 23(35): 4027 - 4036

Maria Giulia Battelli, Letizia Polito, Massimo Bortolotti and Andrea Bolognesi


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Osteoimmunology and Beyond

, 2016; 23(33): 3754 - 3774

Lia Ginaldi and Massimo De Martinis


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Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

, 2016; 23(26): 2908 - 2928

Katarzyna Popiolek-Barczyk and Joanna Mika


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Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review

, 2016; 23(25): 2874 - 2891

Thomas Scior, Jose Antonio Guevara-Garcia, Quoc-Tuan Do, Philippe Bernard and Stefan Laufer


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A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines

, 2016; 23(20): 2112 - 2131

Wojciech Filipiak, Pawel Mochalski, Anna Filipiak, Clemens Ager, Raquel Cumeras, Cristina E. Davis, Agapios Agapiou, Karl Unterkofler and Jakob Troppmair


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Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

, 2016; 23(17): 1725 - 1755

Mieke De Buck, Mieke Gouwy, Ji Ming Wang, Jacques Van Snick, Ghislain Opdenakker, Sofie Struyf and Jo Van Damme


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Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps

, 2016; 23(10): 1062 - 1081

Hannah Y. Mahmood, Shirin Jamshidi, J. Mark Sutton and Khondaker M. Rahman


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Food Proteins as Source of Opioid Peptides-A Review

, 2016; 23(9): 893 - 910

Swati Garg, Kulmira Nurgali and Vijay Kumar Mishra


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Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

, 2016; 23(8): 792 - 815

Marisa Cabeza, Araceli Sánchez-Márquez, Mariana Garrido, Aylín Silva and Eugene Bratoeff


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Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease

, 2016; 23(7): 686 - 700

Ikuko Miyazaki and Masato Asanuma


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Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

, 2016; 23(7): 667 - 685

Gergő A. Molnár, Szilárd Kun, Eszter Sélley, Melinda Kertész, Lívia Szélig, Csaba Csontos, Katalin Böddi, Lajos Bogár, Attila Miseta and István Wittmann


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Eosinophils in Cancer: Favourable or Unfavourable?

, 2016; 23(7): 650 - 666

Samy Sakkal, Sarah Miller, Vasso Apostolopoulos and Kulmira Nurgali


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A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial Quinolone

, 2016; 23(6): 520 - 577

Gregory S. Bisacchi and Michael R. Hale


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Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation

, 2016; 23(5): 408 - 430

Eleonore Fröhlich


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Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging

, 2015; 22(31): 3631 - 3651

Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl


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Non-Traditional Systemic Treatments for Diabetic Retinopathy: An Evidence-Based Review

, 2015; 22(21): 2580 - 2589

Rafael Simo, Stefania Ballarini, Jose Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet and Tien Y Wong


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Bacteriophages and Phage-Derived Proteins – Application Approaches

, 2015; 22(14): 1757 - 1773

Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek and Barbara Maciejewska


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Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis

, 2015; 22(7): 799 - 818

Ralf Hausmann, Achim Kless and Gunther Schmalzing


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Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

, 2015; 22(3): 373 - 404

Natalia Guzior, Anna Wi eckowska, Dawid Panek and Barbara Malawska


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Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols

, 2015; 22(1): 150 - 164

C. Carpene, S. Gomez-Zorita, S. Deleruyelle and M.A. Carpene


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Interactions Between Nanosized Materials and the Brain

, 2014; 21(37): 4200 - 4214

M. Simko and Mats-Olof Mattsson


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A Common Molecular Motif Characterizes Extracellular Allosteric Enhancers of GPCR Aminergic Receptors and Suggests Enhancer Mechanism of Action

, 2014; 21(32): 3673 - 3686

Robert Root-Bernstein and Patrick F. Dillon


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Atrial Natriuretic Peptide: A Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators

, 2014; 21(21): 2401 - 2409

A. Serafino and P. Pierimarchi


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In Vitro and In Vivo Models for Analysis of Resistance to Anticancer Molecular Therapies

, 2014; 21(14): 1595 - 1606

Roberta Rosa, Francesca Monteleone, Nicola Zambrano and Roberto Bianco


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Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers

, 2014; 21(14): 1569 - 1582

G. Ilardi, N. Zambrano, F. Merolla, M. Siano, S. Varricchio, M. Vecchione, G. De Rosa, M. Mascolo and S. Staibano


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Exogenous Hormonal Regulation in Breast Cancer Cells by Phytoestrogens and Endocrine Disruptors

, 2014; 21(9): 1129 - 1145

A. Albini, C. Rosano, G. Angelini, A. Amaro, A.I. Esposito, S. Maramotti, D.M. Noonan and U. Pfeffer


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Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

, 2014; 21(6): 663 - 688

G. Curia, C. Lucchi, J. Vinet, F. Gualtieri, C. Marinelli, A. Torsello, L. Costantino and G. Biagini


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Phytoestrogens in Postmenopause: The State of the Art from a Chemical, Pharmacological and Regulatory Perspective

, 2014; 21(4): 417 - 436

Elisabetta Poluzzi, Carlo Piccinni, Emanuel Raschi, Angela Rampa, Maurizio Recanatini and Fabrizio De Ponti


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An Update on Autoinflammatory Diseases

, 2014; 21(3): 261 - 269

F. Ciccarelli, M. De Martinis and L. Ginaldi


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An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular Mechanisms and Clinical Implications

, 2013; 20(37): 4758 - 4776

A. Cárdeno, M. Sánchez-Hidalgo and C. Alarcón-de-la-Lastra


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Reduction of Breast Cancer Relapses with Perioperative Non-Steroidal Anti-Inflammatory Drugs: New Findings and a Review

, 2013; 20(33): 4163 - 4176

Michael Retsky, Romano Demicheli, William J.M. Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme and Jayant S. Vaidya


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Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction

, 2013; 20(32): 4050 - 4059

S. L. Martin, T. M. Hardy and T. O. Tollefsbol


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Neuroprotective Properties of Curcumin in Alzheimer’s Disease – Merits and Limitations

, 2013; 20(32): 3955 - 3985

Dawn Chin, Patricia Huebbe, Kathrin Pallauf and Gerald Rimbach


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Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics

, 2013; 20(31): 3855 - 3871

Tomo Yonezawa, Riho Kurata, Kaori Yoshida, Masanori A. Murayama, Xiaofeng Cui and Akihiko Hasegawa


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Tuberculosis Clinical Trial Update and the Current Anti-Tuberculosis Drug Portfolio

, 2013; 20(30): 3785 - 3796

Juan Carlos Palomino and Anandi Martin


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A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir

, 2013; 20(30): 3733 - 3742

I. Gentile, F. Borgia, A. R. Buonomo, G. Castaldo and G. Borgia


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Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

, 2013; 20(30): 3677 - 3692

Y. Yang, S. Karakhanova, J. Werner and A. V. Bazhin


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MicroRNAs and Cancer Therapy – From Bystanders to Major Players

, 2013; 20(29): 3561 - 3573

Cornelia Braicu, George A. Calin and Ioana Berindan-Neagoe


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Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications

, 2013; 20(26): 3241 - 3250

Maxwell S. Stem and Thomas W. Gardner


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Mitochondria Damage in the Pathogenesis of Diabetic Retinopathy and in the Metabolic Memory Associated with its Continued Progression

, 2013; 20(26): 3226 - 3233

Renu A. Kowluru


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Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids

, 2013; 20(25): 3174 - 3185

M. H. Branquinha, F. A. Marinho, L. S. Sangenito, S. S.C. Oliveira, K. C. Goncalves, V. Ennes-Vidal, C. M. d’Avila-Levy and A. L.S. Santos


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Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy

, 2013; 20(25): 3116 - 3133

L. O. Santos, A. S. Garcia-Gomes, M. Catanho, C. L. Sodre, A. L.S. Santos, M. H. Branquinha and C. M. d’Avila-Levy


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Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis

, 2013; 20(25): 3103 - 3115

I. M.D. Bastos, F. N. Motta, P. Grellier and J. M. Santana


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Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis

, 2013; 20(25): 3078 - 3102

A. A. Rascon and J. H. McKerrow


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n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity

, 2013; 20(24): 2953 - 2963

R. Crupi, A. Marino and S. Cuzzocrea


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An Overview on Natural Polysaccharides with Antioxidant Properties

, 2013; 20(23): 2899 - 2913

H. Wang, Y. M. Liu, Z. M. Qi, S. Y. Wang, S. X. Liu, X. Li, H. J. Wang and X. C. Xia


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Virtual Screening Strategies in Drug Discovery: A Critical Review

, 2013; 20(23): 2839 - 2860

A. Lavecchia and C. Di Giovanni


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Trypanosomatidae Diseases: From the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery

, 2013; 20(21): 2673 - 2696

L.S.C. Bernardes, C.L. Zani and I. Carvalho


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Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action

, 2013; 20(21): 2641 - 2660

G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou and C. Stefanadis


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Bioavailability of Quercetin: Problems and Promises

, 2013; 20(20): 2572 - 2582

X. Cai, Z. Fang, J. Dou, A. Yu and G. Zhai


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Clinical and Marketed Proteasome Inhibitors for Cancer Treatment

, 2013; 20(20): 2537 - 2551

Jiankang Zhang, Peng Wu and Yongzhou Hu


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Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam

, 2013; 20(19): 2415 - 2437

C. Scarpignato


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Insulin Secretion and Interleukin-1β Dependent Mechanisms in Human Diabetes Remission After Metabolic Surgery

, 2013; 20(18): 2374 - 2388

Chih-Yen Chen, Wei-Jei Lee, A. Asakawa, N. Fujitsuka, Keong Chong, Shu-Chun Chen, Shou-Dong Lee and A. Inui


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1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-Covalent Inhibition of the Human 20S Proteasome

, 2013; 20(18): 2351 - 2362

X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal and B.O. Villoutreix


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Luminescent Silica Nanoparticles for Cancer Diagnosis

, 2013; 20(17): 2195 - 2211

W. Arap, R. Pasqualini, M. Montalti, L. Petrizza, L. Prodi, E. Rampazzo, N. Zaccheroni and S. Marchio


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Computational Peptidology: A New and Promising Approach to Therapeutic Peptide Design

, 2013; 20(15): 1985 - 1996

P. Zhou, C. Wang, Y. Ren, C. Yang and F. Tian


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Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells

, 2013; 20(15): 1923 - 1945

Giuliana Cassinelli, Valentina Zuco, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo and Paola Perego


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Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy

, 2013; 20(14): 1858 - 1886

Jiyang Li, Guangqiang Li and Wenqing Xu


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RNAi in Clinical Studies

, 2013; 20(14): 1801 - 1816

P. Kubowicz, D. Zelaszczyk and E. Pekala


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Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products

, 2013; 20(13): 1673 - 1685

X. Chen and M. Decker


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Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases

, 2013; 20(13): 1662 - 1672

W. J. Geldenhuys and C. J. Van der Schyf


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The Economics of Polypharmacology: Fixed Dose Combinations and Drug Cocktails

, 2013; 20(13): 1635 - 1638

A. I. Wertheimer


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Camptothecin Resistance in Cancer: Insights into the Molecular Mechanisms of a DNA-Damaging Drug

, 2013; 20(12): 1541 - 1565

G. L. Beretta, L. Gatti, P. Perego and N. Zaffaroni


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Long-Acting Beta-Agonists and their Association with Inhaled Corticosteroids in COPD

, 2013; 20(12): 1477 - 1495

L. Fuso, N. Mores, S. Valente, M. Malerba and P. Montuschi


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Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial

, 2013; 20(10): 1323 - 1331

S. Bo, G. Ciccone, A. Castiglione, R. Gambino, F. De Michieli, P. Villois, M. Durazzo, P. Cavallo-Perin and M. Cassader


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Serenoa Repens, Lycopene and Selenium: A Triple Therapeutic Approach to Manage Benign Prostatic Hyperplasia

, 2013; 20(10): 1306 - 1312

L. Minutoli, A. Bitto, F. Squadrito, H. Marini, N. Irrera, G. Morgia, A. Passantino and D. Altavilla


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Ion Channels as Drug Targets in Central Nervous System Disorders

, 2013; 20(10): 1241 - 1285

A. M. Waszkielewicz, A. Gunia, N. Szkaradek, K. Sloczynska, S. Krupinska and H. Marona


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Plant Metabolomics: From Holistic Data to Relevant Biomarkers

, 2013; 20(8): 1056 - 1090

Jean-Luc Wolfender, Serge Rudaz, Young Hae Choi and Hye Kyong Kim


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From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant

, 2013; 20(8): 1005 - 1017

Shan He and Xiaojun Yan


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Antimicrobial Plant Metabolites: Structural Diversity and Mechanism of Action

, 2013; 20(7): 932 - 952

N.S. Radulovic, P.D. Blagojevic, Z.Z. Stojanovic-Radic and N.M. Stojanovic


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The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications

, 2013; 20(7): 908 - 931

A. Alqahtani, K. Hamid, A. Kam, K.H. Wong, Z. Abdelhak, V. Razmovski-Naumovski, K. Chan, K.M. Li, P.W. Groundwater and G.Q. Li


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Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles

, 2013; 20(6): 794 - 814

Martine Demeunynck and Isabelle Baussanne


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Glyconanoparticles-An Update

, 2013; 20(6): 782 - 788

Gangliang Huang


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Honey as a Source of Dietary Antioxidants: Structures, Bioavailability and Evidence of Protective Effects Against Human Chronic Diseases

, 2013; 20(5): 621 - 638

Josè M. Alvarez-Suarez, Francesca Giampieri and Maurizio Battino


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Treatment of Estrogen Receptor-Positive Breast Cancer

, 2013; 20(5): 596 - 604

F. Lumachi, A. Brunello, M. Maruzzo, U. Basso and S. M.M. Basso


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The Current Status of Sweat Testing For Drugs of Abuse: A Review

, 2013; 20(4): 545 - 561

N. De Giovanni and N. Fucci


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New Chemotherapeutic Strategies Against Malaria, Leishmaniasis and Trypanosomiases

, 2013; 20(4): 502 - 526

M. Zucca, S. Scutera and D. Savoia


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Do Subjects at Clinical High Risk for Psychosis Differ from those with a Genetic High Risk? - A Systematic Review of Structural and Functional Brain Abnormalities

, 2013; 20(3): 467 - 481

R. Smieskova, J. Marmy, A. Schmidt, K. Bendfeldt, A. Riecher-Rossler, M. Walter, U. E. Lang and S. Borgwardt


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Volumetric Changes in the Basal Ganglia After Antipsychotic Monotherapy: A Systematic Review

, 2013; 20(3): 438 - 447

B. H. Ebdrup, H. Norbak, S. Borgwardt and B. Glenthoj


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Transcranial Brain Stimulation in Schizophrenia: Targeting Cortical Excitability, Connectivity and Plasticity

, 2013; 20(3): 405 - 413

A. Hasan, P. Falkai and T. Wobrock


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Abnormal Striatal Dopamine Transmission in Schizophrenia

, 2013; 20(3): 397 - 404

Jerome Brunelin, Shirley Fecteau and Marie-Francoise Suaud-Chagny


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Serotonin Receptors of Type 6 (5-HT6): From Neuroscience to Clinical Pharmacology

, 2013; 20(3): 371 - 377

Donatella Marazziti, Stefano Baroni, Franco Borsini, Michela Picchetti, Elena Vatteroni, Valentina Falaschi and Mario Catena-Dell’Osso


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Metabolomics Analysis for Biomarker Discovery: Advances and Challenges

, 2013; 20(2): 257 - 271

M.S. Monteiro, M. Carvalho, M.L. Bastos and P. Guedes de Pinho


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Histone Methyltransferase Inhibitors: Novel Epigenetic Agents for Cancer Treatment

, 2013; 20(2): 167 - 185

C. Zagni, U. Chiacchio and A. Rescifina


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Polymer Nanoparticles - A Novel Strategy for Administration of Paclitaxel in Cancer Chemotherapy

, 2012; 19(36): 6207 - 6213

G. Deepa, N. Ashwanikumar, J. J. Pillai and G. S.V. Kumar


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Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and λ-Amino Acids

, 2012; 19(36): 6178 - 6187

E. Forro and F. Fulop


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Alveolar Epithelial Stem and Progenitor Cells: Emerging Evidence for their Role in Lung Regeneration

, 2012; 19(35): 6003 - 6008

A. M. Hoffman and E. P. Ingenito


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Stem Cells, Self-Renewal and Cancer of the Gastric Epithelium

, 2012; 19(35): 5975 - 5983

Werner Hoffmann


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Store-Dependent Ca2+ Entry in Endothelial Progenitor Cells As a Perspective Tool to Enhance Cell-Based Therapy and Adverse Tumour Vascularization

, 2012; 19(34): 5802 - 5818

F. Moccia, S. Dragoni, F. Lodola, E. Bonetti, C. Bottino, G. Guerra, U. Laforenza, V. Rosti and F. Tanzi


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Polarization of Calcium Signaling and Fluid Secretion in Salivary Gland Cells

, 2012; 19(34): 5774 - 5781

I. S. Ambudkar


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Signal Transduction Pathways of the Epidermal Growth Factor Receptor in Colorectal Cancer and their Inhibition by Small Molecules

, 2012; 19(33): 5735 - 5744

T. Efferth


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Contribution of Oxidative Metabolism to Cocaine-Induced Liver and Kidney Damage

, 2012; 19(33): 5601 - 5606

M.J. Valente, F. Carvalho, M.d.L. Bastos, P.G. de Pinho and M. Carvalho


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Adiponectin: Key Player in the Adipose Tissue-Liver Crosstalk

, 2012; 19(32): 5467 - 5473

A. R. Moschen, V. Wieser and H. Tilg


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Protective Role of Adiponectin in Cardiovascular Disease

, 2012; 19(32): 5459 - 5466

R. Shibata, T. Murohara and N. Ouchi


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A Targeted Therapy for Protein and Lipid Kinases in Chronic Lymphocytic Leukemia

, 2012; 19(31): 5294 - 5318

P. Robak and T. Robak


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Immunoliposomes

, 2012; 19(31): 5239 - 5277

E. Paszko and M.O. Senge


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Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence

, 2012; 19(30): 5148 - 5156

P.S.S. Rao and Y. Sari


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Fragment Based Drug Design: From Experimental to Computational Approaches

, 2012; 19(30): 5128 - 5147

A. Kumar, A. Voet and K.Y.J. Zhang


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From Metallodrugs to Metallodendrimers for Nanotherapy in Oncology: A Concise Overview

, 2012; 19(29): 4995 - 5010

S. El Kazzouli, N. El Brahmi, S. Mignani, M. Bousmina, M. Zablocka and J. -P. Majoral


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Fluorescent Dendrimers As Sensors for Biologically Important Metal Cations

, 2012; 19(29): 4976 - 4983

I. Grabchev, D. Staneva and R. Betcheva


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Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

, 2012; 19(28): 4850 - 4860

V. Sanchez-Valle, N. C. Chavez-Tapia, M. Uribe and N. Mendez-Sanchez


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Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging

, 2012; 19(28): 4742 - 4758

M. Bai and D. J. Bornhop


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New Strategies Against Prostate Cancer – Pt(II)-Based Chemotherapy

, 2012; 19(27): 4678 - 4687

C. S. Matos, A. L.M.B. de Carvalho, R. P. Lopes and M. P.M. Marques


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Review Metabolomics: A New Approach to Drug Delivery in Perinatology

, 2012; 19(27): 4654 - 4661

L. Atzori, J. L. Griffin, A. Noto and V. Fanos


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Peptides As Therapeutics with Enhanced Bioactivity

, 2012; 19(26): 4451 - 4461

D. Goodwin, P. Simerska and I. Toth


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Biology and Clinical Management of Myeloproliferative Neoplasms and Development of the JAK Inhibitor Ruxolitinib

, 2012; 19(26): 4399 - 4413

J. Mascarenhas, T. I. Mughal and S. Verstovsek


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Insights into Targeting Colon Cancer Cell Fate at the Level of Proteoglycans / Glycosaminoglycans

, 2012; 19(25): 4247 - 4258

D. Nikitovic, G. Chatzinikolaou, J. Tsiaoussis, A. Tsatsakis, N. K. Karamanos and G. N. Tzanakakis


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The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment

, 2012; 19(25): 4218 - 4238

M. Stiborova, T. Eckschlager, J. Poljakova, J. Hrabeta, V. Adam, R. Kizek and E. Frei


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Physicochemical Strategies for Inhibition of Amyloid Fibril Formation: An Overview of Recent Advances

, 2012; 19(24): 4157 - 4174

R. Liu, R. Su, M. Liang, R. Huang, M. Wang, W. Qi and Z. He


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Chromogranin-A: A Multifaceted Cardiovascular Role in Health and Disease

, 2012; 19(24): 4042 - 4050

T. Angelone, R. Mazza and M. C. Cerra


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Glutathione-Related Factors and Oxidative Stress in Autism, A Review

, 2012; 19(23): 4000 - 4005

A. Ghanizadeh, S. Akhondzadeh, M. Hormozi, A. Makarem, M. Abotorabi-Zarchi and A. Firoozabadi


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Role of PARP Inhibitors in Cancer Biology and Therapy

, 2012; 19(23): 3907 - 3921

D. Davar, J. H. Beumer, L. Hamieh and H. Tawbi


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Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors

, 2012; 19(22): 3763 - 3778

Polamarasetty Aparoy, Kakularam Kumar Reddy and Pallu Reddanna


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Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

, 2012; 19(22): 3748 - 3762

D. A. Altomare and A. R. Khaled


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Combinatorial Nanoparticles for Cancer Diagnosis and Therapy

, 2012; 19(22): 3714 - 3721

A. Mukerjee, A. P. Ranjan and J. K. Vishwanatha


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Survivin as a Prognostic/Predictive Marker and Molecular Target in Cancer Therapy

, 2012; 19(22): 3679 - 3688

F. Rodel, T. Sprenger, B. Kaina, T. Liersch, C. Rodel, S. Fulda and S. Hehlgans


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Antimicrobial and Biofilm Inhibiting Diketopiperazines

, 2012; 19(21): 3564 - 3577

M. P. de Carvalho and W.-R. Abraham


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Recent Progress in the Development of Agonists and Antagonists for Melatonin Receptors

, 2012; 19(21): 3532 - 3549

D. P. Zlotos


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Designed Multiple Ligands: Basic Research vs Clinical Outcomes

, 2012; 19(20): 3353 - 3387

L. Costantino and D. Barlocco


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Radiolabelled Agents for PET Imaging of Tumor Hypoxia

, 2012; 19(20): 3282 - 3289

H. Kurihara, N. Honda, Y. Kono and Y. Arai


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Drug Targeting to Cancer by Nanoparticles Surface Functionalized with Special Biomolecules

, 2012; 19(19): 3188 - 3195

M. A. Holgado, L. Martin-Banderas, J. Alvarez-Fuentes, M. Fernandez-Arevalo and J. L. Arias


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Drug-Loaded Nanocarriers: Passive Targeting and Crossing of Biological Barriers

, 2012; 19(19): 3070 - 3102

J. M. Rabanel, V. Aoun, I. Elkin, M. Mokhtar and P. Hildgen


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Recent Progress and Future Potential for Metal Complexes as Anticancer Drugs Targeting G-quadruplex DNA

, 2012; 19(18): 2957 - 2975

J. Zhang, F. Zhang, H. Li, C. Liu, J. Xia, L. Ma, W. Chu, Z. Zhang, C. Chen, S. Li and S. Wang


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Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

, 2012; 19(18): 2901 - 2917

R. Masella, C. Santangelo, M. D’Archivio, G. LiVolti, C. Giovannini and F. Galvano


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Chelating Agents for the Treatment of Systemic Iron Overload

, 2012; 19(17): 2816 - 2827

Y. Ma, T. Zhou, X. Kong and R. C. Hider


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Iron Chelators for the Treatment of Cancer

, 2012; 19(17): 2689 - 2702

Y. Yu, E. Gutierrez, Z. Kovacevic, F. Saletta, P. Obeidy, Y. Suryo Rahmanto and D. R. Richardson


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The Role of microRNAs in Cardiovascular Disease

, 2012; 19(16): 2605 - 2610

N. Papageorgiou, D. Tousoulis, E. Androulakis, G. Siasos, A. Briasoulis, G. Vogiatzi, A.-M. Kampoli, E. Tsiamis, C. Tentolouris and C. Stefanadis


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Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations

, 2012; 19(16): 2504 - 2520

R. Lee, M. Margaritis, K. M. Channon and C. Antoniades


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Role of microRNAs in Gynecological Pathology

, 2012; 19(15): 2406 - 2413

J. Gilabert-Estelles, A. Braza-Boils, L. A. Ramon, E. Zorio, P. Medina, F. Espana and A. Estelles


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CuAAC Click Chemistry Accelerates the Discovery of Novel Chemical Scaffolds as Promising Protein Tyrosine Phosphatases Inhibitors

, 2012; 19(15): 2399 - 2405

X. -P. He, J. Xie, Y. Tang, J. Li and G. -R. Chen


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The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

, 2012; 19(14): 2176 - 2228

T.J. Schmidt, S.A. Khalid, A.J. Romanha, T.MA. Alves, M.W. Biavatti, R. Brun, F.B. Da Costa, S.L. de Castro, V.F. Ferreira, M.V.G. de Lacerda, J.H.G. Lago, L.L. Leon, N.P. Lopes, R.C. das Neves Amorim, M. Niehues, I.V. Ogungbe, A.M. Pohlit, M.T. Scotti, W.N. Setzer, M. de N.C. Soeiro and M. Steindel and A.G. Tempone


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Anti-Inflammatory Iridoids of Botanical Origin

, 2012; 19(14): 2104 - 2127

A. Viljoen, N. Mncwangi and I. Vermaak


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Anti-Inflammatory Agents from Plants: Progress and Potential

, 2012; 19(14): 2088 - 2103

M.C. Recio, I. Andujar and J.L. Rios


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Activity of Epiisopiloturine Against Schistosoma mansoni

, 2012; 19(13): 2051 - 2058

L. M. Veras, M. A. Guimaraes, Y. D. Campelo, M. M. Vieira, C. Nascimento, D. F. Lima, L. Vasconcelos, E. Nakano, S. S. Kuckelhaus, M. C. Batista, J. R. Leite and J. Moraes


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Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

, 2012; 19(13): 1946 - 2025

A. Palmeira, E. Sousa, M. H. Vasconcelos and M. M. Pinto


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Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

, 2012; 19(12): 1751 - 1764

B. Frey, Y. Rubner, R. Wunderlich, E.-M. Weiss, A.G. Pockley, R. Fietkau and U.S. Gaipl


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