Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(3): 248-259.

Author(s): Erika C Claud.

Affiliation: University of Chicago, Department of Pediatrics and Medicine, Section of Neonatology and Gastroenterology, 5841 S. Maryland Ave MC6060, Chicago, IL 60637, USA.


Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.


Neonatal necrotizing enterocolitis, premature infant, probiotic, human milk, platelet activating factor, nuclear factor kappaB.

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Article Details

Volume: 8
Issue Number: 3
First Page: 248
Last Page: 259
Page Count: 12
DOI: 10.2174/187152309789152020
Price: $58

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