Anatomical and Functional Relationships Between Sensory Nerves and Mast Cells

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Anatomical and Functional Relationships Between Sensory Nerves and Mast Cells

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(1): 10-17.

Author(s): Fatma Tore and Nese Tuncel.

Affiliation: Abant Izzet Baysal University, Faculty of Medicine, Department of Physiology, Bolu, Turkey.


Mast cell and sensory nerve relationships fall into three categories: proximity, communication and a shared fate. Mast cells are found in all tissues of the human body, especially located closely to nerves. Mast-nerve membrane to membrane contact is a highly common configuration. This should be by design rather than by accident since such spatial distributions generally indicate a functional relationship. Mast cells associated to sensory nerves contain abundant neuropeptides and also a range of neuropeptide receptors enabling nerve to mast cell, mast cell to nerve and reciprocal communications which form the basis of neuroimmune interfacing. Wondering about the possible effects of this intimacy and communication potential on several physiological and pathophysiological events, specifically on diseases with low success rates of therapy and mysterious mechanisms, scientists have uncovered many aspects of mast-nerve interactions. In light of these studies, from a focal point between the nervous and immune systems, mast cells highlight the concept of collaboration as an indispensable building block of the neuroimmune system.


CGRP, Neurogenic inflammation, Neuropeptide, Mast cell, Sensory nerve, Substance P, Tumor necrosis factor (TNF), Peptidergic nerve, Clostridium difficile, Atopic dermaititis (AD).

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Article Details

Volume: 10
Issue Number: 1
First Page: 10
Last Page: 17
Page Count: 8
DOI: 10.2174/187152311795325550

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