Anti-Inflammatory Adjuvant Agents in Bacterial Meningitis

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Anti-Inflammatory Adjuvant Agents in Bacterial Meningitis



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 1(1): 55-62.

Author(s): M. Van der Flier, S. P.M. Geelen and J LL Kimpen.

Affiliation: UMC / Wilhelmina Children's Hospital, HP KB 03.023.2, PO Box 85090, 3508 AB Utrecht, The Netherlands

Abstract

Bacterial meningitis is associated with high morbidity and mortality in both children and adults. The overall mortality rate from bacterial meningitis is 5-10% despite the availability of effective antibiotics and 5-40% of the survivors has severe sequelae. Work in animal models has demonstrated that the host inflammatory response induced by bacterial products in the subarachnoid space in bacterial meningitis is associated with central nervous system (CNS) injury. This has led to the concept that attenuation of inflammation early in the disease process might improve outcome. The increased understanding of the pathogenesis of inflammation and CNS damage has suggested rational targets to modulate the host inflammatory response and prevent irreversal neuronal injury. This review focuses on the adjuvant use of corticosteroids, pentoxifylline, and other agents in bacterial meningitis. In addition novel potential targets such as transcription factor NFκB and caspases are discussed.

Keywords:

Anti-Inflammatory Adjuvant Agents, Bacterial, caspases, interleukin-1 beta, tumor necrosis factor-alpha tnf, corticosteroids, non-steroidal anti-inflammatory drugs.



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Article Details

Volume: 1
Issue Number: 1
First Page: 55
Last Page: 62
Page Count: 8
DOI: 10.2174/1568014024606575
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