Role of CD14 in Host Response to Infection

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


Download PDF Flyer




Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Role of CD14 in Host Response to Infection



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 1(3): 205-210.

Author(s): A Verbon.

Affiliation: Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

Abstract

CD14 may be considered as the major receptor of lipopolysaccharide (LPS), the causative factor of Gramnegative shock. CD14 is expressed on the surface of myeloid cells and is present in the serum as a soluble isoform. In this review both forms of CD14 and their biological functions are discussed. Emphasis is placed upon their differential role in infections. Possibilities and problems of the CD14 blockade during infection in animal models are summarized. Blockade of cellular activation by anti-CD14 antibodies diminishes bacterial clearance, whereas bacterial clearance is enhanced in CD14 knock-out mice, which completely lack both soluble CD14 and membrane bound CD14. These data suggest that therapeutic strategies using CD14 blockade should take both soluble and membrane bound forms of CD14 into account.

Keywords:

CD14, lipopolysaccharide, Gramnegative shock, myeloid cells.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 1
Issue Number: 3
First Page: 205
Last Page: 210
Page Count: 6
DOI: 10.2174/1568014023355872
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science