Microsomal Prostaglandin E Synthase: A Key Enzyme in PGE2 Biosynthesis and Inflammation

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Microsomal Prostaglandin E Synthase: A Key Enzyme in PGE2 Biosynthesis and Inflammation



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 1(3): 167-175.

Author(s): P- J. Jakobsson, D. Engblom, A. Ericsson-Dahlstrand and A Blomqvist.

Affiliation: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden

Abstract

Inducible, glutathione-dependent microsomal prostaglandin E synthase (mPGES) catalyzes the formation of prostaglandin (PG) E2 from cyclooxygenase (COX) derived PGH2. There is a strong association between mPGES and COX-2 protein expression in various cells and tissues. The same types of proinflammatory stimuli induce both enzymes and they co-localize in the cells. In cancer, however, the expression of these two enzymes seems uncoordinated, a fact that should be considered when interpreting recent data from clinical trials testing nonsteroidal anti-inflammatory drugs (NSAIDs) as chemoprotectants against cancer. The importance of mPGES for induced PGE2 biosynthesis was recently demonstrated in mice lacking mPGES. This review intends to summarize briefly the data that have been published on mPGES and discuss the assumed pathophysiological roles of this enzyme in inflammation, atherosclerosis, cancer, and in centrally mediated responses to inflammation.

Keywords:

Microsomal Prostaglandin, glutathione, PGE2 Biosynthesis, Key Enzyme, cyclooxygenase, chemoprotectants.



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Article Details

Volume: 1
Issue Number: 3
First Page: 167
Last Page: 175
Page Count: 9
DOI: 10.2174/1568014023355926
Price: $58
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