From Hygiene Hypothesis to Novel Allergic Asthma Therapeutics

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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From Hygiene Hypothesis to Novel Allergic Asthma Therapeutics



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2(2): 143-155.

Author(s): I. Sayers, G. Le Gros and J L Harper.

Affiliation: Malaghan Institute of Medical Research PO Box 7060 Wellington New Zealand.

Abstract

The prevalence and severity of allergic asthma is increasing worldwide. Epidemiological evidence suggests that the increase in disease prevalence is inversely associated with the occurrence of childhood infections. Specific pathogens, and pathogen-derived components have now been identified that can suppress allergic disease in mice and humans. These discoveries highlight the potential of these microorganisms as a new source of immunotherapeutics. The utility and mechanism of action of these pathogens or pathogen-derived components will be discussed in the context of providing a novel approach for the treatment of allergic airway disease.

Keywords:

allergic asthma, mycobacteria, cpg oligonucleotides, vaccine, mouse models, human trials.



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Article Details

Volume: 2
Issue Number: 2
First Page: 143
Last Page: 155
Page Count: 13
DOI: 10.2174/1568014033483842
Price: $58
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