NF-κB and Proteinuric Renal Disease

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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NF-κB and Proteinuric Renal Disease



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2(1): 29-36.

Author(s): Karina Drumm and Michael Gekle.

Affiliation: Institute of Physiology University of Wuerzburg Roentgenring 9 D-97070 Wuerzburg, Germany

Abstract

Chronic renal diseases with enhanced glomerular protein filtration are accompanied by tubulointerstitial inflammation and progression to renal function deterioration. Filtered protein, like albumin, is a pathogenic factor per se in the progression of renal diseases. The nuclear factor κB (NF-κB), a ubiquitous transcription factor, mediates the expression of numerous inflammatory or fibrotic mediators such as RANTES, MCP-1, TNF-α, cytokine receptors, or iNOS in renal as well as in other tissues. It is evident that NF-κB is involved in protein-overload stimulated renal inflammatory mechanisms. This paper reviews the recent studies concerning NF-κB-activation and expression inducing renal inflammation and fibrosis in several proteinuric animal experimental models as well as protein-induced NF-κBmediated renal inflammatory signal transduction pathways in vitro, with a special focus on albumin-endocytosis in proximal tubular cells. Protein-induced NF-κB-activation and NF-κB-mediated signal transduction pathways seem to be interesting therapeutic targets in proteinuric renal diseases. Therefore, this paper shows recent pharmaceutical approaches to inhibit renal NF-κB-activity.

Keywords:

renal proximal tubule, kidney, inflammation, albumin, proteinuria.



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Article Details

Volume: 2
Issue Number: 1
First Page: 29
Last Page: 36
Page Count: 8
DOI: 10.2174/1568014033355772
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