Hydrophilic Dual Vitamin E-Like Antioxidants as Modulators of Inflammatory Response in Low-Flow States and Impaired Wound Healing

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Hydrophilic Dual Vitamin E-Like Antioxidants as Modulators of Inflammatory Response in Low-Flow States and Impaired Wound Healing



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2(3): 265-273.

Author(s): D. Altavilla, M. Galeano, H. Marini and F Squadrito.

Affiliation: Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology,University of Messina, AOU “G. Martino”. Via Consolare Valeria, Policlinico, Gazzi, Torre Biologica 5 Piano, 98125 Messina Italy.

Abstract

Hydrophilic 2,3-dihydro-5-hydroxy-2-benzofuranacetic acids were designed to maximize the antioxidants potency of phenols and are also chemically related to α-tocopherol. Besides quenching free radicals and blocking the chain breaking reaction, these compounds may act as modulators of the inflammatory cascade triggered by oxidative stress. In fact they block the activation of Nuclear Factor Kappa B (NF-kB) induced by okadaik acid, H2O2, phorbol ester, ceramide and LPS. In addition, in vivo they reduce the inflammatory response reaction and display a marked protection in hemorrhagic shock, septic shock, and myocardial ischemia-reperfusion injury. The persistence of the inflammatory phase has detrimental consequences for the process of wound repair. Increased lipid peroxidation has been shown to play an important role in the wound healing disorders of diabetes: indeed it may prolong the inflammatory phase and significantly alter the mechanisms of angiogenesis. Hydrophilic dual vitamin E-like antioxidants have the capacity to modulate the inflammatory phase and to improve the altered angiogenesis therefore suggesting a possible role in the management of diabetic foot ulcer.

Keywords:

vitamin e-like antioxidants, inflammatory response, low-flow states, wound healing, antioxidants, tocopherol.



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Article Details

Volume: 2
Issue Number: 3
First Page: 265
Last Page: 273
Page Count: 9
DOI: 10.2174/1568014033483707
Price: $58
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