The Physiology of Nitric Oxide: Control and Consequences

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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The Physiology of Nitric Oxide: Control and Consequences

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 3(3): 189-205.

Author(s): Ingrid Fleming and Rudi Busse.

Affiliation: Institut fur KardiovaskulärePhysiologie, Klinikum der J.W.G.-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany


Since its recognition as an endothelium-derived relaxing factor, the control and consequences of nitric oxide (NO) production has been investigated intensely. NO is not simply a vasodilator or regulator of smooth muscle tone but is a potent anti-platelet agent, neuromodulator and regulator of gene expression. This article reviews the mechanisms (intracellular Ca2+, phosphorylation and protein-protein interaction) that regulate the activity of each of the NO synthase isoforms and describes the physiology of NO in the circulation, kidney, skeletal muscle as well as in endocrine, immune and nervous systems.


blood pressure, gene expression, phosphorylation, platelets, protein-protein association, reactive oxygen species, signal transduction, vascular tone.

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Article Details

Volume: 3
Issue Number: 3
First Page: 189
Last Page: 205
Page Count: 17
DOI: 10.2174/1568014043355366
Price: $58

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