Update on Current and Future Pharmacologic Therapy of COPD

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 16, 3 Issues, 2017


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Update on Current and Future Pharmacologic Therapy of COPD



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 3(2): 81-101.

Author(s): L. Brandolini, M. Allegretti, S. Colagioia, R. Novellini, F. Colotta, R. Bertini and G Melillo.

Affiliation: Dompe Research and Development, Dompe s.p.a., L'Aquila, Italy.

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality in the world and the impact of this respiratory pathology is expected to increase over the coming years. Currently available information suggests that genetic factors, environmental factors and genotype-environment interactions influence the disease. This complex pathology is characterised by airflow obstruction, which is generally progressive and largely irreversible. It is always associated with structural remodeling and chronic inflammation of the respiratory tract and neutrophils, macrophages and CD8+ lymphocytes all appear to participate in the inflammatory process. Several therapeutic classes of compounds are used in the treatment of COPD such as bronchodilators, corticosteroids and antibiotics (in the treatment of exacerbations caused by bacterial infections). Although these therapies improve the clinical symptoms and decrease the airway inflammation, they do not reduce significantly the long-term progression of the disease. Thus, new drugs that may affect the underlying causes of COPD such as the inflammatory and destructive processes of the disease are required. The aim of this review is to provide a critical evaluation of current pharmacotherapy in COPD and an overview of new therapeutic strategies for the treatment of this progressive disorder.

Keywords:

chronic obstructive pulmonary disease, airway inflammation, current therapy, new approaches, new treatment.



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Article Details

Volume: 3
Issue Number: 2
First Page: 81
Last Page: 101
Page Count: 21
DOI: 10.2174/1568014043355429
Price: $58
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