Cysteinyl Leukotriene Receptor Antagonists and Thromboxane Synthase Inhibitors: New Targets to Treat Asthma

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Cysteinyl Leukotriene Receptor Antagonists and Thromboxane Synthase Inhibitors: New Targets to Treat Asthma

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 3(1): 9-18.

Author(s): Lidia M. Lima, Carlos Alberto M. Fraga and Eliezer J Barreiro.

Affiliation: Instituto de Quimica, Universidade Federal do Rio de Janeiro - CP 68006 - ZIP 21944-190 Rio de Janeiro, RJ, Brazil


Cysteinyl leukotrienes (LTC 4 , LTD4 and LTE4 ) and thromboxane A2 are important metabolites of arachidonic acid cascate involved in a variety of cellular functions and diseases. These eicosanoids have been implicated as key mediators in the development and progression of bronchial asthma. Therefore, several new therapeutic approaches are based on the design of drugs that can modulate their actions. These strategies can be represented by drugs that act as CysLT1 receptor antagonists (e.g., zafirlukast and montelukast), by inhibiting thromboxane synthase (e.g. ozagrel hydrochloride), or even as new symbiotic agents that can simultaneously modulate the actions of cysteinyl leukotrienes and thromboxane A2 (e.g. YM 158 and LASSBio 341).


asthma, cysteinyl leukotrienes receptors antagonists, thromboxane synthase inhibitors, dual agents, symbiotic agents.

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Article Details

Volume: 3
Issue Number: 1
First Page: 9
Last Page: 18
Page Count: 10
DOI: 10.2174/1568014043483526
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

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