Lymphocyte Homing to the Liver

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Lymphocyte Homing to the Liver



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 3(4): 331-339.

Author(s): Tohru Sato, Henrik Thorlacius and Eugene Butcher.

Affiliation: Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, MC154B, Palo Alto, CA 94304, USA.

Abstract

The liver has a large population of resident lymphocytes that survey the liver under normal conditions but can be rapidly expanded through recruitment and proliferation in response to various insults. The tissue-specific homing molecules for tissues such as intestine and skin are well characterized, but liver-specific homing molecules are still not known. The molecules that have been implicated in liver homing are also selectins, integrins, and chemokines, as in other tissues, however, the unique flow conditions, architecture, and specialized cell populations allow different molecules to play prominent roles in various microenvironments within the liver. In this review, we take a closer look at adhesion molecules (selectins, α4β7, α4β1, αLβ2, and vascular adhesion protein-1) and “inflammatory” chemokine receptors (CXCR3, CCR5, and CXCR6) under various inflammatory conditions and compartments within the liver. Their prominent roles in accumulating lymphocytes to inf lamed liver suggest its importance as possible therapeutic targets for human liver diseases.

Keywords:

chemokines, homing, integrins, liver, lymphocytes.



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Article Details

Volume: 3
Issue Number: 4
First Page: 331
Last Page: 339
Page Count: 9
DOI: 10.2174/1568014043355258
Price: $58
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