Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


Download PDF Flyer




Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(4): 439-448.

Author(s): Hamid Pour-Jafari, Saeid Ghavami and Subbareddy Maddika.

Affiliation: Genetic Dept., School of Medicine, Hamadan University of Medical Sciences, P.O. Box 515, Hamadan, Iran.

Abstract

This review focuses on the physiology of mitochondria as well as on the role of mitochondrial changes in cancer and in the immune system. After discussing the origin, structure, function and physiology of mitochondria, we focus on mitochondrial damage induced by antiviral and other drugs, reactive oxygen intermediates, physical tests like heat shock and ionizing radiation, hypoxia and hyperoxia. While discussing the effects of these noxious stimuli on mitochondria, we introduce terms such as “mitotoxicity” and “mitotoxins”. Further parts of the review focus on the role of mitochondria in programmed cell death, and mitochondrial dysfunction observed in cancer. A significant portion of the review discusses the role of mitochondrial changes during the aging of the immune system, age-related changes of mitochondrial physiology, and mitochondrial proteins as auto-antigens. Using primary biliary cirrhosis as an example, we illustrate that the autoimmune condition is perpetuated by a pathologic immune response directed towards mitochondrial antigens. Finally we raise several questions, which we believe, need to be answered in order to improve the therapy of cancer autoimmunity and genetic diseases involving mitochondria.

Keywords:

mitochondria, toxicity, mitotoxicity, mitotoxins, dna damage.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 4
Issue Number: 4
First Page: 439
Last Page: 448
Page Count: 10
DOI: 10.2174/1568014054546308
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science