Telomeres, Genomic Instability, DNA Repair and Breast Cancer

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Telomeres, Genomic Instability, DNA Repair and Breast Cancer



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(4): 421-428.

Author(s): S. Panigrahi and S Mai.

Affiliation: Manitoba Institute of Cell Biology, Cancer Care Manitoba, University of Manitoba, 675 McDermotAvenue, Winnipeg, MB, R3E 0V9, Canada.

Abstract

This review describes our current understanding of telomere length polymorphism and organization in breast cancer cells. The key roles of the telomeric DNA protein complexes as protectors of chromosomal ends in normal and cancer cells are under much attention in current research, and here we review some of these issues. In general the functionality of telomeres depends on a number of associated factors, like - (1) the length of the telomeric sequence at a particular chromosomal end, (2) the status of telomerase activity, (3) the telomere associated proteins, (4) the status of subtelomeric heterochromatinization, (5) or associated chromosomal instability. Specifically, in breast cancer, depending on the presence or absence of the mutations in DNA repair proteins the telomere function becomes much more fragile. Some recent studies using modern high performance three-dimensional (3D) imaging technologies indicate that many exciting aspects of this multifaceted telomere research are going to unfold further in the coming years.

Keywords:

senescence, genomic integrity, genomic instability, telomeric crisis, telomeric fusions, neoplastic transformatio, breast cancer.



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Article Details

Volume: 4
Issue Number: 4
First Page: 421
Last Page: 428
Page Count: 8
DOI: 10.2174/1568014054546245
Price: $58
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