Cancer Immunotherapy: Battling Tumors with Gene Vaccines

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Cancer Immunotherapy: Battling Tumors with Gene Vaccines

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(4): 353-365.

Author(s): K. Chlichlia, V. Schirrmacher and R Sandaltzopoulos.

Affiliation: Department of Molecular Biology and Genetics, Democritus University of Thrace, Dimitras 19, 68100Alexandroupolis, Greece.


Gene vaccines against defined antigens represent a novel and promising immunization approach for cancer immunotherapy and for battling infectious diseases. Immunization with plasmid DNA is the simplest gene-based approach. In order to induce protective antitumor immunity, gene vaccines are designed to deliver one or several genes encoding tumor-associated antigens, thereby eliciting or augmenting antigen-specific immune responses. The efficacy of gene vaccines can be significantly improved through integration of advances in immunology and molecular biology. Recent evidences point out the central role of dendritic cells and show the importance of innate immune responses in the induction and enhancement of antigen-specific adaptive immune responses. Hence, manipulations that integrate both tumorassociated antigens and danger signals in the vaccine design, can achieve activation of both innate and adaptive immune responses, thereby overcoming the self-tolerance towards many tumor antigens. Coadministration of genetic adjuvants and optimized prime-boost strategies enhance the efficacy of gene vaccines. In this context, strategies that target antigens of choice to dendritic cells and induce, in vivo, antitumor immune responses are discussed. This review highlights vaccine strategies based on transfer of nucleic acid sequences encoding well-defined tumor-associated antigens and genetic adjuvants to the host in vivo in order to induce successful antitumor immunity.


gene vaccines, dna vaccination, rna, prime-boost, cancer immunotherapy.

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Article Details

Volume: 4
Issue Number: 4
First Page: 353
Last Page: 365
Page Count: 13
DOI: 10.2174/1568014054546290
Price: $58

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