Glucosamine Sulphate in Osteoarthritis: From Symptoms to Structure Modification

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Glucosamine Sulphate in Osteoarthritis: From Symptoms to Structure Modification



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(3): 217-220.

Author(s): Jean-Yves Reginster, Marie-Paule Lecart, Olivier Bruyere and Nansa Burlet.

Affiliation: Bone and Cartilage Metabolism Research Unit, CHU Centre-Ville, Policliniques L. BRULL, Quai Godefroid Kurth 45 (9eme etage), 4020 Liege, Belgium.

Abstract

Several chemical entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate. At any rate, this compound has clearly demonstrated a symptomatic action, mainly in osteoarthritis of the lower limbs, on pain relief and improvement of functional disability. An important issue is that all the conclusive studies with such chemical entities resulted from the use of prescription medicines and not over-thecounter pills of food supplements.

Keywords:

aminosaccharide, glycosaminoglycan, cartilage, osteoarthritic chondrocytes, proteoglycans, rat chondrosarcoma cell line, spinal localizations, ibuprofen, narrowest joint space (njs).



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Article Details

Volume: 4
Issue Number: 3
First Page: 217
Last Page: 220
Page Count: 4
DOI: 10.2174/1568014054065212
Price: $58
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