Inhibition of Type 1 Diabetes Development by Vitamin D Receptor Agonists

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Inhibition of Type 1 Diabetes Development by Vitamin D Receptor Agonists



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(6): 645-651.

Author(s): Luciano Adorini, Giuseppe Penna, Nadia Giarratana, Roberto Mariani and Milan R Uskokovic.

Affiliation: BioXell, Via Olgettina 58, I-20132 Milano, Italy.

Abstract

Vitamin D receptor (VDR) agonists are well-known for their capacity to control calcium metabolism and to regulate growth and differentiation of many cell types. More recently, it has become clear that VDR agonists possess exquisite immunoregulatory properties, mostly by targeting dendritic cells and T cells. These properties have been exploited in the treatment of several Th1-mediated experimental autoimmune diseases, and a considerable body of work documents their beneficial effects in inhibiting the development of type 1 diabetes (T1D), a chronic-progressive autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. This review analyzes the capacity of different VDR agonists to inhibit spontaneous T1D development in the non-obese diabetic (NOD) mouse, and shows that 1α,25-(OH)2-16,23Z-diene-26,27-hexafluoro-19-nor D3 (compound 6) is the most effective analog, among those tested, in delaying and reducing disease progression. Identified mechanisms of action underlying the efficacy of this VDR agonist in inhibiting T1D development in the NOD mouse are also reviewed.

Keywords:

NOD mice, vitamin D analogs, autoimmune diabetes.



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Article Details

Volume: 4
Issue Number: 6
First Page: 645
Last Page: 651
Page Count: 7
DOI: 10.2174/156801405774933197
Price: $58
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