Histamine in Immune Regulation: Possible Roles in Autoimmune Demyelinating Disease of the Central Nervous System

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Histamine in Immune Regulation: Possible Roles in Autoimmune Demyelinating Disease of the Central Nervous System



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(6): 637-643.

Author(s): Rosetta Pedotti and Lawrence Steinman.

Affiliation: Immunology and Muscular Pathology Unit, National Neurological Institute "C. Besta", 21033 Milan, Italy.

Abstract

Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological situations. Besides its well-characterised effects in allergic responses and in acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance, and antibody isotype. In multiple sclerosis (MS), and its animal model of experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine might play an important role. Indeed, blockade of specific histamine receptors has been proven to prevent early acute EAE by reducing encephalitogenic T helper 1 response and altering antigen presentation. A deeper understanding of the mechanisms by which histamine regulates the development and progression of EAE and MS might open new strategies for immune intervention.

Keywords:

dendritic cells, histamine receptor, G-protein-coupled receptors, vasoactive amine sensitisation (VAAS), experimental autoimmune encephalomyelitis.



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Article Details

Volume: 4
Issue Number: 6
First Page: 637
Last Page: 643
Page Count: 7
DOI: 10.2174/156801405774933151
Price: $58
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