All in the Family: The TNF-TNFR Superfamily in the Pathogenesis and Treatment of Rheumatoid Arthritis and other Inflammatory Diseases

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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All in the Family: The TNF-TNFR Superfamily in the Pathogenesis and Treatment of Rheumatoid Arthritis and other Inflammatory Diseases



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(6): 587-596.

Author(s): Nikolay P. Nikolov and Richard M Siegel.

Affiliation: Immunoregulation Unit, Autoimmunity Branch, NIAMS Bldg 10 Rm 9N238, NIH, Bethesda MD 20892, USA.

Abstract

In the last ten years, blockade of the cytokine TNF-alpha has emerged as a powerful new treatment for Rheumatoid Arthritis and related inflammatory disorders. However, differences in efficacy and side effect profiles amongst TNF antagonists have revealed important differences in their mechanisms of action. In addition, TNF is only one of more than nineteen related cytokines in the TNF superfamily, each of which plays a distinct role in immune system homeostasis and function. Blocking agents against other members of the TNF family are in development and hold promise in the treatment of Rheumatoid Arthritis and other autoimmune disorders. Recent progress in the understanding of the biology and effects of antagonizing therapeutically relevant TNF family members will be reviewed.

Keywords:

lymphotoxin (LT), peptide-analog antagonists, gene knockout mice, anti-tumor necrosis factor, B lymphocyte stimulator, OX40 receptor-ligand.



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Article Details

Volume: 4
Issue Number: 6
First Page: 587
Last Page: 596
Page Count: 10
DOI: 10.2174/156801405774933133
Price: $58
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