TNF, Cell Death and Inflammation

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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TNF, Cell Death and Inflammation



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(6): 557-567.

Author(s): Jacqueline Bixby, Tathagat D. Ray and Francis KM Chan.

Affiliation: Department of Pathology, Immunology and Virology Program, University of Massachusetts MedicalSchool, 55 Lake Avenue North, Worcester, MA 01655, USA.

Abstract

Tumor necrosis factor (TNFα) is a pleiotropic cytokine that mediates diverse biological responses. In the immune system, TNFα facilitates many aspects of immune responses against pathogenic challenges. While TNFα plays a critical role in the immune defense against pathogens, hyper-activation of the TNFα signaling cascade often results in the development of inflammatory and autoimmune diseases. Examination of natural mutations in human and experimental mouse models that affect TNFα-TNF receptor interaction or their downstream signaling components confirm the importance of this cytokine/receptor pair in the inflammatory process and immunity. Blockade of TNF-TNF receptor interaction has been highly successful in treating several autoimmune diseases including rheumatoid arthritis and Crohns disease. The pro-inflammatory effects of TNFα can be achieved through several distinct signaling mechanisms including the activation of NF-kB and programmed cell death. In this review, we discuss recent advances in our understanding of the mechanisms by which TNFα induces different forms of programmed cell death and the role they play in mediating the inflammatory response. Specifically, we discuss how the induction of a recently defined cell death pathway, programmed necrosis, by TNFα may contribute to the activation of innate immune responses and the inflammatory process.

Keywords:

Apoptosis, programmed necrosis, programmed cell death, TNF, TNF receptor, RIP, inflammation.



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Article Details

Volume: 4
Issue Number: 6
First Page: 557
Last Page: 567
Page Count: 11
DOI: 10.2174/156801405774933214
Price: $58
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