IFN-γ: Detection and Prevention of Release

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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IFN-γ: Detection and Prevention of Release

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(2): 121-131.

Author(s): Theresa L Whiteside.

Affiliation: University of Pittsburgh Cancer Institute, Research Pavilion at the Hillman Cancer Center, Suite 1.27,5117 Centre Avenue, Pittsburgh, PA 15213, USA.


Interferon g (IFN-γ) is a regulatory cytokine with a broad spectrum of biologic activities and considerable clinical importance. It is considered to be a master regulator of the immune system. Many human diseases, including infections, cancer and autoimmunity, are associated with aberrant production of IFN-γ. Detection and regulation of IFN-γ production is an important clinical objective. Today, levels of IFN-γ in body fluids and tissues can be reproducibly measured by a variety of assays, including single-cell assays, that are discussed below. Strategies for inhibition of IFN-γ secretion depend on immunologic, pharmacologic or genetic interventions. Increasingly, molecular approaches based on inhibition of IFN-γ signaling pathways are considered for down-regulation of excessive IFN-γ production in various pathologic conditions.


cytokines, natural killer (nk) cells, signaling, t cell receptor (tcr), inducible nitric oxide synthase (inos), macrophage, expression.

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Article Details

Volume: 4
Issue Number: 2
First Page: 121
Last Page: 131
Page Count: 11
DOI: 10.2174/1568014053507096
Price: $58

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