NKT Cells: A Regulator in Both Innate and Acquired Immunity

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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NKT Cells: A Regulator in Both Innate and Acquired Immunity



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 4(1): 59-64.

Author(s): Ken-ichiro Seino and Masaru Taniguchi.

Affiliation: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Suehirocho1-7-22, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

Abstract

CDd-restricted NKT cells are a unique subset of lymphocytes bridging innate and acquired immunity and mediating both effector and regulatory functions in immune responses. NKT cells are essential for the protection against pathogens or tumors, and also play a regulatory role in transplantation tolerance and autoimmune disease development. This review focuses on the various functions of NKT cells and discusses fundamental mechanisms in NKT cell biology.

Keywords:

immune system, natural killer (nk) cells, dendritic cells (dcs), lymphocytes, cytokines, transcription.



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Article Details

Volume: 4
Issue Number: 1
First Page: 59
Last Page: 64
Page Count: 6
DOI: 10.2174/1568014053005282
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