Inflammation and Pancreatic Cancer: Recent Development with Focusing on Potential New Drug Targets

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Inflammation and Pancreatic Cancer: Recent Development with Focusing on Potential New Drug Targets



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(5): 351-357.

Author(s): Generoso Uomo, Luigi Laghi and Raffaele Pezzilli.

Affiliation: Internal Medicine Department, Unit 3, Cardarelli Hospital, Via Cardarelli 9, 80131 Napoli, Italy.

Abstract

Chronic inflammation has been identified as a significant factor in the carcinogenesis of various tumors, including pancreatic cancer. Both hereditary and classical forms of chronic pancreatitis are associated with an increased risk of developing pancreatic cancer. Cytokines and other mediators of the inflammatory process together with an upregulation of pro-inflammatory pathways play a pivotal role in oncogenesis stimulation, tumor growth and metastasis. The presence of a strong desmoplastic reaction within and around pancreatic cancer cells renders the proteolytic degradation of extracellular matrix components an essential process for tumor invasion and metastasis. Various classes of proteases produced by the pancreatic acinar cells are involved in these proteolytic events. The multiple link between inflammation and pancreatic cancer may represent the basis for a novel antineoplastic strategy. Cytokines, proteases, reactive-oxygen-species, cyclooxygenase-2, nuclear-factor-κB and perixosome proliferator-activated receptor-γ may be a new molecular targets useful for therapeutic purpose.

Keywords:

Cyclooxygenase-2, cytokines, gabexate mesilate, nuclear-factor-kappaB, pancreatic neoplasms, pancreatitis, chronic, perixosome proliferator-activated receptor-gamma, proteases, reactive oxygen species, stromal cells.



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Article Details

Volume: 10
Issue Number: 5
First Page: 351
Last Page: 357
Page Count: 7
DOI: 10.2174/1871523011109050351
Price: $58
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