Mucoadhesive Buccal Systems as a Novel Strategy for Anti-Inflammatory Drugs Administration

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Mucoadhesive Buccal Systems as a Novel Strategy for Anti-Inflammatory Drugs Administration



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(3): 190-202.

Author(s): Ana Figueiras, Amelia Vieira, Susana Simoes and Francisco Veiga.

Affiliation: Faculdade de Ciencias da Saude, Universidade da Beira Interior, 6200-506 Covilha, Portugal.

Abstract

This is a review article that intends to emphasize the advantages of buccal delivery as an alternative route of administration of anti-inflammatory drugs. The oral cavity has a number of features that make it desirable for drug administration: a rich blood supply that drains directly into the jugular vein, thus bypassing the liver and sparing the drug from first pass metabolism. To understand this point of view, some considerations are done relatively to the oral mucosal structural characteristics with relevance to drug administration, oral mucosal permeability, as well as drug absorption mechanisms through oral cavity. However, to design a buccal delivery system, it is necessary to take in account the residence time of drug formulation in the buccal mucosa. Mucoadhesion mechanism can be a solution to overcome this limitation. For this reason the main buccoadhesive pharmaceutical forms are approached, as well as the importance of oral mucosal in buccal anti-inflammatory drug delivery systems in terms of future perspectives.

Keywords:

Anti-inflammatory drugs, buccal mucosa, buccoadhesive drug delivery systems, Transcellular Route, Paracellular Route, Molecular Weight, Penetration Enhancers, MUCOADHESION, Mucoadhesive Polymers, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).



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Article Details

Volume: 10
Issue Number: 3
First Page: 190
Last Page: 202
Page Count: 13
DOI: 10.2174/1871523011109030190
Price: $58
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