Pharmaceutical Approaches for Optimizing Oral Anti-Inflammatory Delivery Systems

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Pharmaceutical Approaches for Optimizing Oral Anti-Inflammatory Delivery Systems



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(3): 154-165.

Author(s): Lopes C.M., Oliveira R. and Silva AC.

Affiliation: Faculty of Health Sciences,Fernando Pessoa University, Rua Carlos da Maia, 296, P-4200-150 Porto,Portugal.

Abstract

The purpose of the present review is to compile the recent literature in the field of anti-inflammatory treatments, with special focus to the state-of-the-art on pharmaceutical approaches for optimizing oral administration. Attending to the drawbacks associated with the use of these types of drugs, the development of oral modulated release formulations is highly desirable in order to achieve improved therapeutic efficacy and patient compliance. Several technological systems and their advantages in modulated and targeted drug releases (gastroretention or colonic release) have been described: matrix systems, coated dosage forms, osmotic pressure based formulations, prodrugs, colloidal carriers, microparticles and other carriers. These new approaches seem to be promising and have been considered by pharmaceutical companies.

Keywords:

Anti-inflammatory drugs, matrix systems, coated systems, osmotic systems, prodrugs, colloidal carriers, microparticles, gastroretentive systems, colon systems, coated dosage forms.



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Article Details

Volume: 10
Issue Number: 3
First Page: 154
Last Page: 165
Page Count: 12
DOI: 10.2174/1871523011109030154
Price: $58
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