The Capsaicin Paradox: Pain Relief by an Algesic Agent

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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The Capsaicin Paradox: Pain Relief by an Algesic Agent

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(1): 52-65.

Author(s): Gabor Jancso, Orsolya Oszlacs and Peter Santha.

Affiliation: H-6720, Szeged, Dom ter 10, Hungary.


Chemosensitive primary sensory neurones expressing the TRPV1 receptor, a molecular integrator of diverse noxious stimuli, play a fundamental role in the sensation of pain. Capsaicin, the archetypical ligand of the TRPV1 receptor, is one of the most painful chemical irritants, and its acute administration onto the skin and mucous membranes elicits severe pain. However, repeated or high-dose applications of capsaicin, and/or its administration through specific routes dramatically decreases the sensitivity of the innervated tissues to noxious chemical and heat stimuli. This review surveys the mechanisms of the antinociceptive, anti-inflammatory and anti-hyperalgesic effects of vanilloid agonists applied topically, or perineurally, or injected into the subarachnoid space in animal experiments and to put these data into a clinical perspective. The great body of available experimental evidence indicates that vanilloid agonists exert their antinociceptive actions through TRPV1 receptor-mediated selective neurotoxic/neurodegenerative effects directed against somatic and visceral C-fibre nociceptive primary afferent fibres. It is expected that vanilloid agonists will broaden the palette of analgesic drugs which do not cause addiction and tachyphylaxis.


Analgesia, capsaicin, neurogenic inflammation, pain management, primary sensory neurone, spinal cord, TRPV1, Sensory efferent, Vasodilation.

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Article Details

Volume: 10
Issue Number: 1
First Page: 52
Last Page: 65
Page Count: 14
DOI: 10.2174/187152311795325514

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