Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(1): 43-51.

Author(s): Ceng Luo, Rou-Gang Xie and San-Jue Hu.

Affiliation: Institute of Neuroscience, Fourth Military Medical University, 17 West Chang-le Road, Xi'an, 710032, China.

Abstract

Pain and inflammation are considered strongly associated. The greater pain behavior was demonstrated in animals with greater amount of inflammation. Tissue or nerve injury results in the release of various inflammatory mediators such as prostaglandins, bradykinin, proinflammatory cytokines, chemokines, histamine, serotonin and nerve growth factors from the site of injury. These inflammatory mediators play a critical role in both integrating the inflammatory response and mediating pain hypersensitivity. This review highlights the role of prostaglandins and proinflammatory cytokines in the pain sensitization and its underlying mechanisms, emphasizing the evidence that these molecules are potential targets to develop novel drugs and therapies for the treatment of both inflammation and pain in clinic.

Keywords:

Inflammation, pain, prostaglandins, proinflammatory cytokines, hyperalgesia, bradykinin, COX, Tetrodotoxin (TTX) resistant, Tumor- necrosis factor- alpha (TNF- ), GlucocortiCoids.



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Article Details

Volume: 10
Issue Number: 1
First Page: 43
Last Page: 51
Page Count: 9
DOI: 10.2174/187152311795325497
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