An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

Download PDF Flyer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Claudiu T. Supuran
Neurofarba Department
University of Florence

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(1): 2-9.

Author(s): Akio Hiura and Hiroshi Nakagawa.

Affiliation: 770-8508, 3-18-15 Kuramotocho, Tokushima, Japan.


The specific actions of capsaicin on the small primary afferent neurons with regard to neurogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are referred, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by a recent literature survey. TRPV1- expressing nerve fibers were recently reported to be responsible for the itching sensation. Three possible itching pathways were raised. The participation of pure sensory nerve fibers which exclusively transmit itchiness has not been found, as yet.


Capsaicin, histamine, itch, neurogenic inflammation, plasma extravasation, TRPV1, Axon reflex, Antidromic vasodilation, C- fibers, Inorganic polycationic dye.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 10
Issue Number: 1
First Page: 2
Last Page: 9
Page Count: 8
DOI: 10.2174/187152311795325505
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science