The Role of Alpha1-Antitrypsin Deficiency in Respiratory Disease

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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The Role of Alpha1-Antitrypsin Deficiency in Respiratory Disease

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 9(4): 299-303.

Author(s): Noor Kalsheker.

Affiliation: School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.


The main aim of this review is to describe the role of alpha1-antitrypsin deficiency (AATD) in respiratory disease which accounts for over 50% of AATD associated deaths. Only about 10% of all patients with AATD are detected and the majority of cases go undetected or are asymptomatic. Cigarette smoking and other environmental exposures are important triggers for developing respiratory disease. This review examines the spectrum of respiratory manifestations of AATD, the epidemiology of AATD worldwide, the molecular pathophysiology underlying the respiratory component and the role of augmentation therapy in AATD related disease.


Antitrypsin deficiency, respiratory disease, molecular pathology, therapy, alpha1-antitrypsin deficiency (AATD), Chronic obstructive pulmonary disease (COPD), emphysema, hyperinflation, Protease inhibitor (Pi), chronic bronchitis, asthma, forced expiratory, volume in one second (FEV1), bronchiectasis, symptomatic disease, immunisation, dexamethasone, Pi Mmalton, Pi Msiiyama, neutrophil elastase, bronchoalveolar, Alpha1-antitrypsin deficiency, Chronic obstructive pulmonary disease, Forced Expiratory Volume in one second, Protease inhibitor, United States of America.

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Article Details

Volume: 9
Issue Number: 4
First Page: 299
Last Page: 303
Page Count: 5
DOI: 10.2174/1871523011009040299
Price: $58

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