Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 9(3): 212-220.

Author(s): M. Beatriz Currier and Charles B Nemeroff.

Affiliation: Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

Abstract

Increasing evidence suggests that activation of the innate immune system may play a seminal role in the pathophysiology of depression. Several lines of evidence support the association of inflammation and depression. Peripheral administration of cytokines, such as interferon-alpha, can induce many of the symptoms of the depressive syndrome. In addition, medically healthy patients with major depression exhibit elevated plasma levels of proinflammatory cytokines. Moreover, cytokines produce effects on a variety of neurobiological substrates previously implicated in the pathogenesis of depression. Thus, proinflammatory cytokines alter neuroendocrine function, several neurotransmitter systems including dopamine and glutamate, neural plasticity, and neuronal activity in limbic regions. The burgeoning evidence that depression is an inflammatory disease is reviewed.

Keywords:

Inflammation, cytokines, depression, monoamine neurotransmitters, hypothalamic-pituitary-adrenal axis, glutamate.



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Article Details

Volume: 9
Issue Number: 3
First Page: 212
Last Page: 220
Page Count: 9
DOI: 10.2174/1871523011009030212
Price: $58
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