Advances in Biologic Agents for the Treatment of Rheumatoid Arthritis

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

Download PDF Flyer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Claudiu T. Supuran
Neurofarba Department
University of Florence

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Advances in Biologic Agents for the Treatment of Rheumatoid Arthritis

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 9(1): 24-34.

Author(s): Ali Gur and Pelin Oktayoglu.

Affiliation: Department of Physical Medicine and Rehabilitation, Medical Faculty of Gaziantep University, Gaziantep, Turkey.


Rheumatoid arthritis is characterized by pain, swelling, and destruction of joints, with resultant disability. Only disease-modifying antirheumatic drugs can interfere with the disease process. Advances in the current knowledge of pathogenetic mechanisms of rheumatoid arthritis have contributed to the development of biologic agent therapy, and translated research findings into clinical practice. Therapeutics options for rheumatoid arthritis (RA) have increased tremendously in the past decade with the introduction of biologic agents in 1999. Especially inhibitors of tumor necrosis factor have allowed for hitherto unseen therapeutic benefit, although even with these drugs the frequency and degree of responses are restricted. Therefore, new agents are needed. And novel biologic agent compounds for treatment RA have already been used in practice or are on the horizon. TNF-α (infliximab, etanercept, adalimumab), IL-1 (anakinra) and IL-6 (tocilizumab) inhibitors, a B-cell depleting agent (rituximab) and a drug blocking T-cell costimulation (abatacept) have been approved for rheumatoid arthritis. The progress in manufacturing biotechnology has contributed to the development of several other prospective agents that may form the basis for the therapy of rheumatoid arthritis in the near future. The newer biologic agents appear to be well tolerated in the short to medium term (up to 1 year), with an acceptable tolerability profile. However, larger studies with longer follow-up times are needed to indicate both effects and adverse effects of these agents.


Rheumatoid arthritis, biologic agents, TNF-alpha blocker, monoclonal antibody, Disease modifying anti-rheumatic drugs.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 1
First Page: 24
Last Page: 34
Page Count: 11
DOI: 10.2174/187152310790711656
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science