Hapten Recognition by T Cells: A Functional and Molecular View

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Hapten Recognition by T Cells: A Functional and Molecular View



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(4): 366-376.

Author(s): Alessandra Franco.

Affiliation: School of Medicine, Department of Pediatrics, University California San Diego, 9500 Gilman Drive, La Jolla CA 92093-0641, USA.

Abstract

T cells specific for haptens determine immunopathology, as for the recognition of the β-lactamic ring by CD4+ T helper cells, responsible for the severe immune response to Penicillin in allergic patients. In this review we report studies that address functional and molecular aspects of hapten recognition by α/β T cells, enlightening the most relevant examples of hapten-specific T cells and their role in vivo. Using Trinitrophenyl as a contact allergen model and tumor associated carbohydrate antigens (TACA) as antigen models in cancer, our laboratory extensively studied T cell recognition by hapten-specific T cells suggesting new, unexplored avenues for T cell-based immunotherapy. In fact, the evidence of hapten recognition by “conventional” α/β T cells is of a critical importance in designing new immunotherapeutic approaches to treat allergies, cancer and chronic viral diseases.

Keywords:

Haptens, drugs, metals, TACA, antigen presenting cells, T cells, immunotherapy.



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Article Details

Volume: 8
Issue Number: 4
First Page: 366
Last Page: 376
Page Count: 11
DOI: 10.2174/187152309789839019
Price: $58
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