Dual Role of S100A8 and S100A9 in Inflammation-Associated Cancer

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

Download PDF Flyer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Claudiu T. Supuran
Neurofarba Department
University of Florence

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Dual Role of S100A8 and S100A9 in Inflammation-Associated Cancer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(4): 329-336.

Author(s): Julia Nemeth, Peter Angel and Jochen Hess.

Affiliation: Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Division of Signal Transduction and Growth Control (A100), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.


Human cancer is a chronic disease that originates from transformed tumor cells harboring genetic as well as epigenetic alterations. It develops via a multi-step process that can be divided both operationally and mechanistically into three phases: initiation, promotion and progression. However, cancer is not merely an autonomous mass of mutant cells, but is composed of multiple cell types, such as fibroblasts and epithelial cells, innate and adaptive immune cells, and cells forming blood vessels and lymphatic vasculature. A striking feature of many cancers is an underlying persistent and unresolved inflammation, which often orchestrates a tumor supporting microenvironment. Several lines of evidence identified an enhanced expression of S100A8 and S100A9 proteins in pathological conditions of chronic inflammation and inflammation- associated carcinogenesis in patient specimens as well as cell culture and experimental animal models. More recently, the analysis of genetically modified mouse models and cell lines derived thereof has provided important new insights into the regulation and molecular function of S100A8 and S100A9 proteins in vivo and in vitro. In this review, we will summarize our current knowledge on S100A8 and S100A9 regulation and function on tumor cell signaling and survival, as well as the establishment of an inflammatory, pro-tumorigenic microenvironment. Based on this knowledge, this review will discuss potential strategies to interfere with S100A8 and S100A9 function as a novel option to develop innovative strategies for cancer prevention or therapy.



Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 8
Issue Number: 4
First Page: 329
Last Page: 336
Page Count: 8
DOI: 10.2174/187152309789839037
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: urooj@benthamscience.org Copyright © 2017 Bentham Science