Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(2): 164-168.

Author(s): Thorsten Nolting and Gabriele Arendt.

Affiliation: University Hospital of Duesseldorf (UKD), Department of Psychiatry, Bergische Landstrasse 2, 40629 Duesseldorf, Germany.

Abstract

Pharmacogenomics is a relatively new field in HIV-research, especially when neurological issues are concerned. Influence of polymorphisms in CYP3A4, CYP2B6, CYP2D6, ABCB1, ABCG2, ABCC4, SLC22, SLC28, SLC29 and MMP9-genes on pharmacokinetic data is discussed in the article. Due to the lack of published studies, but promising results in the few existing publications, scientists should be encouraged to integrate neurological aspects in pharmacogenomics research.

Keywords:

HIV, CNS, pharmacogenomics, pharmacogenetics, MMP9, SLC, ABC-transporter, cytochrome.



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Article Details

Volume: 8
Issue Number: 2
First Page: 164
Last Page: 168
Page Count: 5
DOI: 10.2174/187152309789152101
Price: $58
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