Probiotics and Gastrointestinal Disease: Clinical Evidence and Basic Science

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Probiotics and Gastrointestinal Disease: Clinical Evidence and Basic Science

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(3): 260-269.

Author(s): Elaine O Petrof.

Affiliation: Queen's University, Dept. of Medicine, GIDRU wing, 76 Stuart St., Kingston, ON K7L 2V7, Canada.


Our intestinal microbiota serve many roles vital to the normal daily function of the human gastrointestinal tract. Many probiotics are derived from our intestinal bacteria, and have been shown to provide clinical benefit in a variety of gastrointestinal conditions. Current evidence indicates that probiotic effects are strain-specific, they do not act through the same mechanisms, and nor are all probiotics indicated for the same health conditions. However, they do share several common features in that they exert anti-inflammatory effects, they employ different strategies to antagonize competing microorganisms, and they induce cytoprotective changes in the host either through enhancement of barrier function, or through the upregulation of cytoprotective host proteins. In this review we focus on a few selected probiotics – a bacterial mixture (VSL), a Gram-negative probiotic (E. coli Nissle 1917), two Gram-positive probiotic bacteria (LGG, L.reuteri), and a yeast probiotic (S. boulardii) – for which sound clinical and mechanistic data is available. Safety of probiotic formulations is also discussed.


Probiotics, intestinal microbiota, inflammation, colitis.

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Article Details

Volume: 8
Issue Number: 3
First Page: 260
Last Page: 269
Page Count: 10
DOI: 10.2174/187152309789151977
Price: $58

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