Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(3): 214-227.

Author(s): Jun Sun.

Affiliation: University of Rochester Medical Center, Department of Medicine, Gastroenterology&Hepatology Division, Box 646, 601 Elmwood Ave., Rochester, NY 14642, USA.

Abstract

Bacteria use multiple strategies to bypass the inflammatory responses in order to survive in the host cells. In this review, we discuss the mechanism of the bacerial proteins in inhibiting inflammation. We highlight the antiinflammatory roles of the type three secretion proteins including Salmonella AvrA, Enteropathogenic Escherichia coli Cif, and Yersinia YopJ, Staphylococcus aureus extracellular adherence protein, and Chlamydia proteins. We also discuss the research progress on the structures of these anti-inflammatory bacterial proteins. The current therapeutic methods for diseases, such as inflammatory bowel diseases, sclerosis, lack influence on the course of chronic inflammation and infection. Therefore, based on the molecular mechanism of the anti-inflammatory bacterial proteins and their 3-Dimension structure, we can design new peptides or non-peptidic molecules that serve as anti-inflammatory drugs without the possible side effect of promoting bacterial infection.

Keywords:

Bacteria, type three secretion system, effector, bacterial-tail-specific protease, inflammation, anti-inflammation, acetylation, ubiquitination, phosphorylation, intestine.



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Article Details

Volume: 8
Issue Number: 3
First Page: 214
Last Page: 227
Page Count: 14
DOI: 10.2174/187152309789151986
Price: $58
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