Biotechnological Approaches for the Treatment of Inflammatory Diseases

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Biotechnological Approaches for the Treatment of Inflammatory Diseases



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(1): 51-71.

Author(s): V. Iansante, D. Capece, S. Murgo, M. M. Mancarelli, F. Zazzeroni and E Alesse.

Affiliation: Department of Experimental Medicine, via Vetoio 10, Coppito II, 67100 L'Aquila, Italy.

Abstract

Chronic inflammation represents a key pathogenetic event of many diseases, such as psoriasis, inflammatory bowel diseases, rheumatoid arthritis, asthma, multiple sclerosis, atherosclerosis, cystic fibrosis, and sepsis. Conventional therapies for many of these disorders do not lead to the resolution of the inflammatory disorder, and frequently are associated with limited effectiveness and severe side effects. For these reasons alternative therapies have been developed, in the attempt to ensure a more sustained therapeutic response. Biotechnological approaches for the development of these novel drugs are giving exciting results: several biologic molecules are now tested in preclinical or clinical trials, and several of them are even approved for marketing.

Keywords:

Inflammatory diseases, recombinant proteins, nucleic acid-based therapy.



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Article Details

Volume: 8
Issue Number: 1
First Page: 51
Last Page: 71
Page Count: 21
DOI: 10.2174/187152309787580793
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