Tumor Necrosis Factor Inhibitors as Therapeutic Choice in Psoriasis

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Tumor Necrosis Factor Inhibitors as Therapeutic Choice in Psoriasis

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(1): 47-50.

Author(s): D. Digiuseppe and C Feliciani.

Affiliation: Istituto di Dermatolgia Policlinico Gemelli, 00168 Roma, Italy.


Psoriasis has been for a long time a distressing skin disease difficult to treat. Several topical and systemic drugs have been used successfully in the treatment but the most active drugs are also the most difficult to manage in a long term treatment. Discovering the pathogenesis of this skin disorder has suggested that anti tumor necrosis factors agents could be an alternative treatment. Up to now several manuscripts show data supporting the idea that anti TNF are safe and effective more than other drugs. On the experience of dermatologists using this drug in a large number of patients TNF inhibitors are very effective drugs with a relatively safe management. At the moment several drug companies are developing a second generation of biologic drugs with different targets. This review point out the actual knowledge about anti TNF drugs and their activities on psoriasis both clinically and biologically.


Psoriasis, therapy, anti TNF, biological agents, tumor necrosis factor.

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Article Details

Volume: 8
Issue Number: 1
First Page: 47
Last Page: 50
Page Count: 4
DOI: 10.2174/187152309787580766

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