Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(1): 22-37.

Author(s): Giuseppe Carlucci.

Affiliation: Universita degli Studi “ G. D'Annunzio” Chieti-Pescara - Facolta di Farmacia - Dipartimento di Scienze del Farmaco - via dei Vestini - 66100 Chieti–Italy.

Abstract

High-performance liquid chromatographic methods for the analysis of cyclooxygenase 2 inhibitors (COX-2) in biological fluids are reviewed. In particular, sample preparation and handling procedures, chromatographic conditions and detection methods are discussed. A summary of published high-performance liquid chromatographic assays for individual nabumetone, celecoxib, rofecoxib, nimesulide, etoricoxib, etodolac, deracoxib, lumiracoxib, valdecoxib, and meloxicam is included.

Keywords:

Sample preparation, NSAIDs, COX-2 inhibitors, biological fluids, HPLC.



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Article Details

Volume: 8
Issue Number: 1
First Page: 22
Last Page: 37
Page Count: 16
DOI: 10.2174/187152309787580829
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