UV Induced Skin Immunosuppression

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


Download PDF Flyer




Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


UV Induced Skin Immunosuppression



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8(1): 3-13.

Author(s): Paolo Amerio, Angelo Carbone, Matteo Auriemma, Stefano Varrati and Antonello Tulli.

Affiliation: Clinica Dermatologica, Universita degli Studi di Chieti-Pescara, Via dei Vestini, 66013 Chieti, Italy.

Abstract

It is well estabilished that ultraviolet radiations from sunlight are carcinogenetic for skin cells. These radiations at different wavelength induce damage in the skin manly through two mechanisms : direct DNA alteration and alteration of the immune system. The skin immune system is composed by a complex network of cells and soluble mediators that help to maintain the homeostasis of the skin. UV induced immunosuppression is mediated through different photoreceptors present in the skin that lead to either: the production of immunosuppressive cytokines such as IL-10, TNF-α and TGF-β or the development of suppressive T regulatory cells or to the migration in the skin of CD11+ leukocytes in the skin that ultimately lead to the suppression of immune responses. The aim of this short review is to summarize the general knowledge in the field of UV-induced immunosuppression. The knowledge of the exact mechanism involved in this mechanism is important in order to develop strategies aimed at reducing skin cancer induction.

Keywords:

Skin, immunosuppression, Ultraviolet light, UV, immunology.



Download Free Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 8
Issue Number: 1
First Page: 3
Last Page: 13
Page Count: 11
DOI: 10.2174/187152309787580775
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science