Molecular Mechanisms in Rheumatic Diseases: Rationale for Novel Drug Development – Introduction

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Molecular Mechanisms in Rheumatic Diseases: Rationale for Novel Drug Development – Introduction



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(2): 73-77.

Author(s): Charles J Malemud.

Affiliation: Department of Medicine,Division of Rheumatic Diseases, University Hospitals Case Medical Center,2061 Cornell Road, Suite 207, Cleveland, Ohio 44106-5076 (USA).

Abstract

Novel therapies for treating rheumatoid arthritis (RA) will largely be developed as a consequence of our improved understanding of immune-mediated inflammatory responses that regulate the progression of the disease process. This Special Mini “Hot-Topic” Issue of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, entitled, Molecular Mechanisms in Rheumatic Diseases: Rationale for Novel Drug Development explores several recent developments in how new drugs will be designed for the therapy of RA by employing proteomic databases and other wellvalidated computational strategies. Furthermore, recent advances in the recognition that pro-inflammatory cytokines and the interferon family of proteins activate intracellular signal transduction pathways which control immune-mediated inflammatory responses as well as the way in which newly identified regulators of inflammation such as the Toll-like receptors contribute to RA are also discussed.

Keywords:

Computational strategies, proinflammatory cytokines, interferons, proteomic databases, signal transduction pathways, Toll-like receptors, lymphocyte, anti-interleukin.



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Article Details

Volume: 10
Issue Number: 2
First Page: 73
Last Page: 77
Page Count: 5
DOI: 10.2174/1871523011107020073
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