Derivatives of IL-16 to Modulate Airway Inflammation

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Derivatives of IL-16 to Modulate Airway Inflammation

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7(4): 281-293.

Author(s): Sophie Laberge and William W Cruikshank.

Affiliation: Sainte-Justine Hospital, 3175 Cote Sainte-Catherine Road, Montreal, Quebec, Canada, H3T 1C5.


The full development of allergic airway responses in asthma is critically dependent on CD4+ T cells. Through interaction with CD4 molecule, IL-16 acts specifically on CD4+ cells. In vitro, IL-16 has been characterized as a chemoattractant for CD4+ immune cells and as a regulator of T cell functions inhibiting T cell receptor-mediated activation, an effect that is more predominant in T 2 cells. IL-16/CD4 interaction also regulates chemokine receptor signaling. The contribution of IL-16 in allergic airway inflammation has been studied both in humans and in animal models of asthma. Airway expression of IL-16 is upregulated in patients with ongoing asthma and in experimental models of allergic airway inflammation. The immunomodulatory function of IL-16 has been demonstrated in murine models of asthma in which systemic treatment with IL-16 inhibits antigen-induced airway responses and T 2 T cell cytokine production. This review addresses the current data regarding IL-16 protein and gene structure; the interaction of IL-16 with CD4; the biological activities of IL-16; its immunoregulatory role in allergic airway inflammation. In addition, we discuss the known and potential therapeutic applications for IL-16 and IL-16 peptide derivatives in allergic airway inflammation.


T cells, immune regulation, asthma, allergy.

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Article Details

Volume: 7
Issue Number: 4
First Page: 281
Last Page: 293
Page Count: 13
DOI: 10.2174/187152308786847825
Price: $58

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