Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7(3): 231-238.

Author(s): Syed Tahir, Anthony Nappi and Navin K Kapur.

Affiliation: Division of Interventional Cardiology, Tufts Medical Center, 750 Washington Street, Boston, MA 02111, USA.


Dating back to the early 1900s, clinical observations have pointed towards an intimate relationship between dyslipidemia, inflammation, and endothelial dysfunction in the pathogenesis of atherosclerosis. Despite a focus on aggressive lowering of low-density lipoprotein cholesterol (LDL-C) in patients at risk for developing cardiovascular disease, only moderate reductions in cardiovascular events have been achieved, suggesting other targets of therapy should be investigated. Over the past two decades pre-clinical and clinical data have demonstrated a direct correlation between inflammation and atheroma development. This review provides a detailed understanding of inflammation in atherogenesis with a particular emphasis on clinical studies correlating markers of inflammation with plaque progression using carotid intima-media thickness measurements and intravascular ultrasound.


Atherosclerosis, inflammation, atherogenesis, soluble markers, intravascular ultrasound, carotid intima-media thickness.

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Article Details

Volume: 7
Issue Number: 3
First Page: 231
Last Page: 238
Page Count: 8
DOI: 10.2174/187152308785699227
Price: $58

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