Periodontitis and Atherosclerosis, a Causal Relationship?

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Periodontitis and Atherosclerosis, a Causal Relationship?



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7(3): 199-205.

Author(s): Francisco Mesa, Ricardo Munoz, Cristina Godoy and Francisco O'Valle.

Affiliation: Facultad de Odontologia, Campus de Cartuja s/n, Universidad de Granada, E-18071 Granada, Spain.

Abstract

Periodontal and atheromatous diseases affect a large proportion of the general population. They have been associated with each other and may be causally linked. It has not proved possible to confirm a causal relationship between periodontitis and atherosclerosis to date and contradictory results have been published, likely due to the multi-factorial nature of these diseases. The Medline database (PubMed) was explored for papers published in English, using a wide search strategy. This review discusses pathophysiological hypotheses on the possible link between atherosclerosis and periodontitis and analyzes the direct effect on the vascular endothelium of periodontopathogens, biochemical markers of chronic inflammation, pro-inflammatory cytokines and the role of atherogenic proteins in periodontitis. The article includes crosssectional, case-control, longitudinal, and interventional studies, and describes the latest meta-analyses published in the literature. Scientific evidence to date indicates that periodontitis is a risk factor for atherosclerosis, but longitudinal studies of large samples are required to determine whether there is a causal relationship between these diseases.

Keywords:

Atherosclerosis, periodontitis, chronic inflammation.



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Article Details

Volume: 7
Issue Number: 3
First Page: 199
Last Page: 205
Page Count: 7
DOI: 10.2174/187152308785699218
Price: $58
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