Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7(3): 152-157.

Author(s): Ana Z Fernandez.

Affiliation: Centro de Biofisica y Bioquimica, I.V.I.C. Apdo 21827, Caracas 1020a, Venezuela.


In the vascular wall of large arteries, cellular and humoral immune responses are elicited as a consequence of diverse noxious stimuli within subendothelial space, which further derives in endothelial dysfunction, the accumulation of lipids and formation of the atheromatous plaque. Monocytes, macrophages, T cells, endothelial cells and smooth muscular cells are all players in this inflammatory-atherosclerotic process, which is not only genetically regulated but also influenced by environmental factors. In this review, the summary of genetic variants in major immune mediators associated with the evolution of atherosclerosis is presented.


Atherosclerosis, genetic polymorphisms, inflammation, cytokines.

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Article Details

Volume: 7
Issue Number: 3
First Page: 152
Last Page: 157
Page Count: 6
DOI: 10.2174/187152308785699272
Price: $58

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