Small Interfering RNAs and their Therapeutic Applications in Mitigation of Virus Replication and Pathological Effects in the Respiratory Tract

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Small Interfering RNAs and their Therapeutic Applications in Mitigation of Virus Replication and Pathological Effects in the Respiratory Tract



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7(2): 116-121.

Author(s): Murray J Cairns.

Affiliation: School of Biomedical Sciences,Faculty of Health, The University of Newcastle, NSW 2308, Australia.

Abstract

Small double stranded RNA molecules known as small interfering RNA (siRNA), initially identified for their role in the guide sequence in the effector complex of the RNA interference pathway, now represent a promising new class of therapeutic agent with potentially important clinical applications for the prevention and treatment of viral disease. siRNA with its ability to harness the cells own gene-silencing apparatus in a highly adaptable and sequence specific manner has demonstrated unprecedented anti-gene activity. This review highlights the key chemical and biological parameters of this technology and its application in viral suppression, particularly in the respiratory tract. This treatment site represents both an important opportunity to establish clinical exposure for the technology, and an important challenge to provide an additional layer of protection against highly threatening influenza epidemics and potential pandemics.

Keywords:

siRNA, RNA interference, influenza, PTGS, respiratory tract, pandemic, liposome and anti-viral.



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Article Details

Volume: 7
Issue Number: 2
First Page: 116
Last Page: 121
Page Count: 6
DOI: 10.2174/187152308784533177
Price: $58
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