Etanercept for the Treatment of Dermatological Diseases

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Etanercept for the Treatment of Dermatological Diseases



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 6(3): 183-187.

Author(s): Goksun Karaman.

Affiliation: Department of Dermatology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.

Abstract

Inhibition of the proinflammatory cytokine TNF-α has been shown to be an effective strategy for treating inflammatory dermatoses. Etanercept competitively inhibits the interaction of TNF, interrupting the proinflammatory cytokine cascade and preventing TNF mediated cellular responses. The success of etanercept in a wide range of dermatologic conditions especially in psoriasis gives a new hope in dermatological therapy field. This article reviews the pharmacokinetic properties, safety profile, administration route and efficacy in different dermatological conditions of etanercept.

Keywords:

tumour necrosis factor aplha, Cytokines, TNF inhibitors, Psoriasis, Inflammatory Diseases.



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Article Details

Volume: 6
Issue Number: 3
First Page: 183
Last Page: 187
Page Count: 5
DOI: 10.2174/187152307781368256
Price: $58
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