The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 6(1): 85-97.

Author(s): Edward Hitti and Alexey Kotlyarov.

Affiliation: Institut fur Biochemie,Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.

Abstract

Sequential activation of kinases (protein kinase cascades) is a general mechanism of signal transduction in many cellular processes. Several related intracellular signaling cascades have been found and characterized in the last 25 years known as mitogen-activated protein kinase (MAPK) signaling cascades. These cascades cooperate in transmitting extracellular signals to their intracellular targets and thus initiate cellular processes such as proliferation, differentiation, development, stress- and inflammatory response, and apoptosis. Each of these signaling cascades consists of protein kinases that sequentially in several steps activate each other by phosphorylation. MAPKs are ubiquitously expressed but regulate a variety of biological responses depending on the cell type. Modulating the function of MAPK pathways by small molecules therefore requires a profound understanding of how MAPKs are integrated in various signaling networks.

Keywords:

MAPK, MAPKAPK, ERK, p38, JNK, TPL2, TTP, gene targeting.



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Article Details

Volume: 6
Issue Number: 1
First Page: 85
Last Page: 97
Page Count: 13
DOI: 10.2174/187152307779939741
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